Lipoteichoic acid from Lactobacillus plantarum elicits both the production of interleukin-23p19 and suppression of pathogen-mediated interleukin-10 in THP-1 cells

Han Geun Kim, Min Geun Gim, Joo Yun Kim, Hyun Jin Hwang, Min Seok Ham, Jung Min Lee, Thomas Hartung, Jung Woo Park, Seung Hyun Han, Dae Kyun Chung

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, the stimulatory effects of different lactic acid bacteria strains, and their subcellular fractions, on the THP-1 cell line were evaluated. Lactobacillus plantarum was found in particular to induce high levels of IL-23p19 mRNA, but it moderately induced TNF-α production. IL-10 production was not entirely affected by L. plantarum stimulation. When subcellular fractions of L. plantarum were used to treat THP-1 cells, IL-23p19 mRNA expression was enhanced in a dose-responsive manner, specifically by lipoteichoic acid (LTA). The cotreatment of THP-1 cells by both L. plantarum and Staphylococcus aureus LTA resulted in decreased IL-10 production when compared with cells treated by S. aureus LTA alone. Taken together, these data suggest that LTA isolated from L. plantarum elicits stimulatory effects upon the expression of IL-23p19 and inhibitory effects on pathogen-mediated IL-10 production.

Original languageEnglish (US)
Pages (from-to)205-214
Number of pages10
JournalFEMS Immunology and Medical Microbiology
Volume49
Issue number2
DOIs
StatePublished - Mar 2007
Externally publishedYes

Keywords

  • Interleukin-10
  • Interleukin-23
  • Lactobacillus plantarum
  • Lipoteichoic acid

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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