Liposarcomas

Aatur D. Singhi, Elizabeth A. Montgomery

Research output: Contribution to journalReview articlepeer-review

Abstract

Liposarcoma is a common soft tissue sarcoma and represents a group of neoplasms, each with distinct clinical behavior and pathologic findings. Proper classification is critical for clinical management and prognostication. Until recently, immunohistochemistry played a limited role in diagnosis of these tumors. Increased understanding of the underlying genetic basis of disease has paved the way for development of improved tools for diagnosis and new forms of targeted therapy. This article summarizes the clinical, pathologic, and molecular findings of the main liposarcoma subtypes. Special attention to the differential diagnosis and difficulties the pathologist may face when interpreting these lesions is discussed.

Original languageEnglish (US)
Pages (from-to)963-994
Number of pages32
JournalSurgical Pathology Clinics
Volume4
Issue number3
DOIs
StatePublished - Sep 2011

Keywords

  • Atypical lipomatous tumor/Well-differentiated liposarcoma
  • Dedifferentiated LPS
  • Liposarcoma
  • Mixed-type LPS
  • Myxoid/Round cell LPS
  • Pleomorphic LPS

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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