Lipoprotein(a) Levels in Patients with Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis

Kazuhiko Kotani, Amirhossein Sahebkar, Maria Corina Serban, Sorin Ursoniu, Dimitri P. Mikhailidis, Giovanni Mariscalco, Steven Jones, Seth Martin, Michael Blaha, Peter P. Toth, Manfredi Rizzo, Karam Kostner, Jacek Rysz, Maciej Banach

Research output: Contribution to journalReview article

Abstract

Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patients with AAA were found to have a significantly higher level of Lp(a) compared to the controls (SMD: 0.87, 95% CI: 0.41-1.33, P <.001). This result remained robust in the sensitivity analysis, and its significance was not influenced after omitting each of the included studies from the meta-analysis. The present meta-analysis confirmed a higher level of circulating Lp(a) in patients with AAA compared to controls. High Lp(a) levels can be associated with the presence of AAA, and Lp(a) may be a marker in screening for AAA. Further studies are needed to establish the clinical utility of measuring Lp(a) in the prevention and management of AAA.

Original languageEnglish (US)
Pages (from-to)99-108
Number of pages10
JournalAngiology
Volume68
Issue number2
DOIs
StatePublished - Feb 1 2017

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Lipoprotein(a)
Abdominal Aortic Aneurysm
Meta-Analysis
Confidence Intervals
PubMed

Keywords

  • abdominal aortic aneurysm
  • biomarker
  • lipoprotein(a)
  • screening

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kotani, K., Sahebkar, A., Serban, M. C., Ursoniu, S., Mikhailidis, D. P., Mariscalco, G., ... Banach, M. (2017). Lipoprotein(a) Levels in Patients with Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis. Angiology, 68(2), 99-108. https://doi.org/10.1177/0003319716637792

Lipoprotein(a) Levels in Patients with Abdominal Aortic Aneurysm : A Systematic Review and Meta-Analysis. / Kotani, Kazuhiko; Sahebkar, Amirhossein; Serban, Maria Corina; Ursoniu, Sorin; Mikhailidis, Dimitri P.; Mariscalco, Giovanni; Jones, Steven; Martin, Seth; Blaha, Michael; Toth, Peter P.; Rizzo, Manfredi; Kostner, Karam; Rysz, Jacek; Banach, Maciej.

In: Angiology, Vol. 68, No. 2, 01.02.2017, p. 99-108.

Research output: Contribution to journalReview article

Kotani, K, Sahebkar, A, Serban, MC, Ursoniu, S, Mikhailidis, DP, Mariscalco, G, Jones, S, Martin, S, Blaha, M, Toth, PP, Rizzo, M, Kostner, K, Rysz, J & Banach, M 2017, 'Lipoprotein(a) Levels in Patients with Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis', Angiology, vol. 68, no. 2, pp. 99-108. https://doi.org/10.1177/0003319716637792
Kotani K, Sahebkar A, Serban MC, Ursoniu S, Mikhailidis DP, Mariscalco G et al. Lipoprotein(a) Levels in Patients with Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis. Angiology. 2017 Feb 1;68(2):99-108. https://doi.org/10.1177/0003319716637792
Kotani, Kazuhiko ; Sahebkar, Amirhossein ; Serban, Maria Corina ; Ursoniu, Sorin ; Mikhailidis, Dimitri P. ; Mariscalco, Giovanni ; Jones, Steven ; Martin, Seth ; Blaha, Michael ; Toth, Peter P. ; Rizzo, Manfredi ; Kostner, Karam ; Rysz, Jacek ; Banach, Maciej. / Lipoprotein(a) Levels in Patients with Abdominal Aortic Aneurysm : A Systematic Review and Meta-Analysis. In: Angiology. 2017 ; Vol. 68, No. 2. pp. 99-108.
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