TY - JOUR
T1 - Lipoprotein(a) Levels in Patients with Abdominal Aortic Aneurysm
T2 - A Systematic Review and Meta-Analysis
AU - Kotani, Kazuhiko
AU - Sahebkar, Amirhossein
AU - Serban, Maria Corina
AU - Ursoniu, Sorin
AU - Mikhailidis, Dimitri P.
AU - Mariscalco, Giovanni
AU - Jones, Steven R.
AU - Martin, Seth
AU - Blaha, Michael J.
AU - Toth, Peter P.
AU - Rizzo, Manfredi
AU - Kostner, Karam
AU - Rysz, Jacek
AU - Banach, Maciej
N1 - Publisher Copyright:
© SAGE Publications.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patients with AAA were found to have a significantly higher level of Lp(a) compared to the controls (SMD: 0.87, 95% CI: 0.41-1.33, P <.001). This result remained robust in the sensitivity analysis, and its significance was not influenced after omitting each of the included studies from the meta-analysis. The present meta-analysis confirmed a higher level of circulating Lp(a) in patients with AAA compared to controls. High Lp(a) levels can be associated with the presence of AAA, and Lp(a) may be a marker in screening for AAA. Further studies are needed to establish the clinical utility of measuring Lp(a) in the prevention and management of AAA.
AB - Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patients with AAA were found to have a significantly higher level of Lp(a) compared to the controls (SMD: 0.87, 95% CI: 0.41-1.33, P <.001). This result remained robust in the sensitivity analysis, and its significance was not influenced after omitting each of the included studies from the meta-analysis. The present meta-analysis confirmed a higher level of circulating Lp(a) in patients with AAA compared to controls. High Lp(a) levels can be associated with the presence of AAA, and Lp(a) may be a marker in screening for AAA. Further studies are needed to establish the clinical utility of measuring Lp(a) in the prevention and management of AAA.
KW - abdominal aortic aneurysm
KW - biomarker
KW - lipoprotein(a)
KW - screening
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U2 - 10.1177/0003319716637792
DO - 10.1177/0003319716637792
M3 - Review article
C2 - 26980774
AN - SCOPUS:85007311106
SN - 0003-3197
VL - 68
SP - 99
EP - 108
JO - Angiology
JF - Angiology
IS - 2
ER -