Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies

C. E. Smith, J. Ngwa, T. Tanaka, Q. Qi, M. K. Wojczynski, R. N. Lemaitre, J. S. Anderson, A. Manichaikul, V. Mikkilä, F. J A Van Rooij, Z. Ye, S. Bandinelli, A. C. Frazier-Wood, D. K. Houston, F. Hu, C. Langenberg, N. M. McKeown, D. Mozaffarian, K. E. North, J. ViikariM. C. Zillikens, L. Djoussé, A. Hofman, M. Kähönen, E. K. Kabagambe, R. J F Loos, G. B. Saylor, N. G. Forouhi, Y. Liu, K. J. Mukamal, Y. Di Chen, M. Y. Tsai, A. G. Uitterlinden, O. Raitakari, C. M. Van Duijn, D. K. Arnett, I. B. Borecki, L. A. Cupples, L. Ferrucci, S. B. Kritchevsky, T. Lehtimäki, Lu Qi, J. I. Rotter, D. S. Siscovick, N. J. Wareham, J. C M Witteman, J. M. Ordovás, J. A. Nettleton

Research output: Contribution to journalArticle

Abstract

Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P

Original languageEnglish (US)
Pages (from-to)1211-1220
Number of pages10
JournalInternational Journal of Obesity
Volume37
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

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Keywords

  • gene-diet interactions
  • Low-density lipoprotein receptor-related protein 1
  • saturated fatty acids
  • SNPs

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Smith, C. E., Ngwa, J., Tanaka, T., Qi, Q., Wojczynski, M. K., Lemaitre, R. N., Anderson, J. S., Manichaikul, A., Mikkilä, V., Van Rooij, F. J. A., Ye, Z., Bandinelli, S., Frazier-Wood, A. C., Houston, D. K., Hu, F., Langenberg, C., McKeown, N. M., Mozaffarian, D., North, K. E., ... Nettleton, J. A. (2013). Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies. International Journal of Obesity, 37(9), 1211-1220. https://doi.org/10.1038/ijo.2012.215