Lipoprotein receptor-related protein 1 variants and dietary fatty acids

Meta-analysis of European origin and African American studies

C. E. Smith, J. Ngwa, T. Tanaka, Q. Qi, M. K. Wojczynski, R. N. Lemaitre, J. S. Anderson, A. Manichaikul, V. Mikkilä, F. J A Van Rooij, Z. Ye, S. Bandinelli, A. C. Frazier-Wood, D. K. Houston, F. Hu, C. Langenberg, N. M. McKeown, D. Mozaffarian, K. E. North, J. Viikari & 28 others M. C. Zillikens, L. Djoussé, A. Hofman, M. Kähönen, E. K. Kabagambe, R. J F Loos, G. B. Saylor, N. G. Forouhi, Y. Liu, K. J. Mukamal, Y. Di Chen, M. Y. Tsai, A. G. Uitterlinden, O. Raitakari, C. M. Van Duijn, D. K. Arnett, I. B. Borecki, L. A. Cupples, L. Ferrucci, S. B. Kritchevsky, T. Lehtimäki, Lu Qi, J. I. Rotter, D. S. Siscovick, N. J. Wareham, J. C M Witteman, J. M. Ordovás, J. A. Nettleton

Research output: Contribution to journalArticle

Abstract

Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P

Original languageEnglish (US)
Pages (from-to)1211-1220
Number of pages10
JournalInternational Journal of Obesity
Volume37
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

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Lipoprotein Receptors
African Americans
Meta-Analysis
Fatty Acids
Genotype
Proteins
Single Nucleotide Polymorphism
Hip
Body Mass Index
Low Density Lipoprotein Receptor-Related Protein-1
Fat Body
Adiposity
Waist Circumference
Energy Intake
Hypothalamus
Population

Keywords

  • gene-diet interactions
  • Low-density lipoprotein receptor-related protein 1
  • saturated fatty acids
  • SNPs

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Lipoprotein receptor-related protein 1 variants and dietary fatty acids : Meta-analysis of European origin and African American studies. / Smith, C. E.; Ngwa, J.; Tanaka, T.; Qi, Q.; Wojczynski, M. K.; Lemaitre, R. N.; Anderson, J. S.; Manichaikul, A.; Mikkilä, V.; Van Rooij, F. J A; Ye, Z.; Bandinelli, S.; Frazier-Wood, A. C.; Houston, D. K.; Hu, F.; Langenberg, C.; McKeown, N. M.; Mozaffarian, D.; North, K. E.; Viikari, J.; Zillikens, M. C.; Djoussé, L.; Hofman, A.; Kähönen, M.; Kabagambe, E. K.; Loos, R. J F; Saylor, G. B.; Forouhi, N. G.; Liu, Y.; Mukamal, K. J.; Chen, Y. Di; Tsai, M. Y.; Uitterlinden, A. G.; Raitakari, O.; Van Duijn, C. M.; Arnett, D. K.; Borecki, I. B.; Cupples, L. A.; Ferrucci, L.; Kritchevsky, S. B.; Lehtimäki, T.; Qi, Lu; Rotter, J. I.; Siscovick, D. S.; Wareham, N. J.; Witteman, J. C M; Ordovás, J. M.; Nettleton, J. A.

In: International Journal of Obesity, Vol. 37, No. 9, 09.2013, p. 1211-1220.

Research output: Contribution to journalArticle

Smith, CE, Ngwa, J, Tanaka, T, Qi, Q, Wojczynski, MK, Lemaitre, RN, Anderson, JS, Manichaikul, A, Mikkilä, V, Van Rooij, FJA, Ye, Z, Bandinelli, S, Frazier-Wood, AC, Houston, DK, Hu, F, Langenberg, C, McKeown, NM, Mozaffarian, D, North, KE, Viikari, J, Zillikens, MC, Djoussé, L, Hofman, A, Kähönen, M, Kabagambe, EK, Loos, RJF, Saylor, GB, Forouhi, NG, Liu, Y, Mukamal, KJ, Chen, YD, Tsai, MY, Uitterlinden, AG, Raitakari, O, Van Duijn, CM, Arnett, DK, Borecki, IB, Cupples, LA, Ferrucci, L, Kritchevsky, SB, Lehtimäki, T, Qi, L, Rotter, JI, Siscovick, DS, Wareham, NJ, Witteman, JCM, Ordovás, JM & Nettleton, JA 2013, 'Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies', International Journal of Obesity, vol. 37, no. 9, pp. 1211-1220. https://doi.org/10.1038/ijo.2012.215
Smith, C. E. ; Ngwa, J. ; Tanaka, T. ; Qi, Q. ; Wojczynski, M. K. ; Lemaitre, R. N. ; Anderson, J. S. ; Manichaikul, A. ; Mikkilä, V. ; Van Rooij, F. J A ; Ye, Z. ; Bandinelli, S. ; Frazier-Wood, A. C. ; Houston, D. K. ; Hu, F. ; Langenberg, C. ; McKeown, N. M. ; Mozaffarian, D. ; North, K. E. ; Viikari, J. ; Zillikens, M. C. ; Djoussé, L. ; Hofman, A. ; Kähönen, M. ; Kabagambe, E. K. ; Loos, R. J F ; Saylor, G. B. ; Forouhi, N. G. ; Liu, Y. ; Mukamal, K. J. ; Chen, Y. Di ; Tsai, M. Y. ; Uitterlinden, A. G. ; Raitakari, O. ; Van Duijn, C. M. ; Arnett, D. K. ; Borecki, I. B. ; Cupples, L. A. ; Ferrucci, L. ; Kritchevsky, S. B. ; Lehtimäki, T. ; Qi, Lu ; Rotter, J. I. ; Siscovick, D. S. ; Wareham, N. J. ; Witteman, J. C M ; Ordovás, J. M. ; Nettleton, J. A. / Lipoprotein receptor-related protein 1 variants and dietary fatty acids : Meta-analysis of European origin and African American studies. In: International Journal of Obesity. 2013 ; Vol. 37, No. 9. pp. 1211-1220.
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TY - JOUR

T1 - Lipoprotein receptor-related protein 1 variants and dietary fatty acids

T2 - Meta-analysis of European origin and African American studies

AU - Smith, C. E.

AU - Ngwa, J.

AU - Tanaka, T.

AU - Qi, Q.

AU - Wojczynski, M. K.

AU - Lemaitre, R. N.

AU - Anderson, J. S.

AU - Manichaikul, A.

AU - Mikkilä, V.

AU - Van Rooij, F. J A

AU - Ye, Z.

AU - Bandinelli, S.

AU - Frazier-Wood, A. C.

AU - Houston, D. K.

AU - Hu, F.

AU - Langenberg, C.

AU - McKeown, N. M.

AU - Mozaffarian, D.

AU - North, K. E.

AU - Viikari, J.

AU - Zillikens, M. C.

AU - Djoussé, L.

AU - Hofman, A.

AU - Kähönen, M.

AU - Kabagambe, E. K.

AU - Loos, R. J F

AU - Saylor, G. B.

AU - Forouhi, N. G.

AU - Liu, Y.

AU - Mukamal, K. J.

AU - Chen, Y. Di

AU - Tsai, M. Y.

AU - Uitterlinden, A. G.

AU - Raitakari, O.

AU - Van Duijn, C. M.

AU - Arnett, D. K.

AU - Borecki, I. B.

AU - Cupples, L. A.

AU - Ferrucci, L.

AU - Kritchevsky, S. B.

AU - Lehtimäki, T.

AU - Qi, Lu

AU - Rotter, J. I.

AU - Siscovick, D. S.

AU - Wareham, N. J.

AU - Witteman, J. C M

AU - Ordovás, J. M.

AU - Nettleton, J. A.

PY - 2013/9

Y1 - 2013/9

N2 - Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P

AB - Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P

KW - gene-diet interactions

KW - Low-density lipoprotein receptor-related protein 1

KW - saturated fatty acids

KW - SNPs

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U2 - 10.1038/ijo.2012.215

DO - 10.1038/ijo.2012.215

M3 - Article

VL - 37

SP - 1211

EP - 1220

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

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