Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies

C. E. Smith; J. Ngwa; T. Tanaka; Q. Qi; M. K. Wojczynski; R. N. Lemaitre; J. S. Anderson; A. Manichaikul; V. Mikkilä; F. J A Van Rooij; Z. Ye; S. Bandinelli; A. C. Frazier-Wood; D. K. Houston; F. Hu; C. Langenberg; N. M. McKeown; D. Mozaffarian; K. E. North; J. Viikari; M. C. Zillikens; L. Djoussé; A. Hofman; M. Kähönen; E. K. Kabagambe; R. J F Loos; G. B. Saylor; N. G. Forouhi; Y. Liu; K. J. Mukamal; Y. Di Chen; M. Y. Tsai; A. G. Uitterlinden; O. Raitakari; C. M. Van Duijn; D. K. Arnett; I. B. Borecki; L. A. Cupples; L. Ferrucci; S. B. Kritchevsky; T. Lehtimäki; Lu Qi; J. I. Rotter; D. S. Siscovick; N. J. Wareham; J. C M Witteman; J. M. Ordovás; J. A. Nettleton

doi:10.1038/ijo.2012.215

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies

C. E. Smith, J. Ngwa, T. Tanaka, Q. Qi, M. K. Wojczynski, R. N. Lemaitre, J. S. Anderson, A. Manichaikul, V. Mikkilä, F. J A Van Rooij, Z. Ye, S. Bandinelli, A. C. Frazier-Wood, D. K. Houston, F. Hu, C. Langenberg, N. M. McKeown, D. Mozaffarian, K. E. North, J. ViikariM. C. Zillikens, L. Djoussé, A. Hofman, M. Kähönen, E. K. Kabagambe, R. J F Loos, G. B. Saylor, N. G. Forouhi, Y. Liu, K. J. Mukamal, Y. Di Chen, M. Y. Tsai, A. G. Uitterlinden, O. Raitakari, C. M. Van Duijn, D. K. Arnett, I. B. Borecki, L. A. Cupples, L. Ferrucci, S. B. Kritchevsky, T. Lehtimäki, Lu Qi, J. I. Rotter, D. S. Siscovick, N. J. Wareham, J. C M Witteman, J. M. Ordovás, J. A. Nettleton

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P

Original language	English (US)
Pages (from-to)	1211-1220
Number of pages	10
Journal	International Journal of Obesity
Volume	37
Issue number	9
DOIs	https://doi.org/10.1038/ijo.2012.215
State	Published - Sep 2013
Externally published	Yes

Keywords

gene-diet interactions
Low-density lipoprotein receptor-related protein 1
saturated fatty acids
SNPs

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Endocrinology, Diabetes and Metabolism

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10.1038/ijo.2012.215

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Smith, C. E., Ngwa, J., Tanaka, T., Qi, Q., Wojczynski, M. K., Lemaitre, R. N., Anderson, J. S., Manichaikul, A., Mikkilä, V., Van Rooij, F. J. A., Ye, Z., Bandinelli, S., Frazier-Wood, A. C., Houston, D. K., Hu, F., Langenberg, C., McKeown, N. M., Mozaffarian, D., North, K. E., ... Nettleton, J. A. (2013). Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies. International Journal of Obesity, 37(9), 1211-1220. https://doi.org/10.1038/ijo.2012.215

Smith, CE, Ngwa, J, Tanaka, T, Qi, Q, Wojczynski, MK, Lemaitre, RN, Anderson, JS, Manichaikul, A, Mikkilä, V, Van Rooij, FJA, Ye, Z, Bandinelli, S, Frazier-Wood, AC, Houston, DK, Hu, F, Langenberg, C, McKeown, NM, Mozaffarian, D, North, KE, Viikari, J, Zillikens, MC, Djoussé, L, Hofman, A, Kähönen, M, Kabagambe, EK, Loos, RJF, Saylor, GB, Forouhi, NG, Liu, Y, Mukamal, KJ, Chen, YD, Tsai, MY, Uitterlinden, AG, Raitakari, O, Van Duijn, CM, Arnett, DK, Borecki, IB, Cupples, LA, Ferrucci, L, Kritchevsky, SB, Lehtimäki, T, Qi, L, Rotter, JI, Siscovick, DS, Wareham, NJ, Witteman, JCM, Ordovás, JM & Nettleton, JA 2013, 'Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies', International Journal of Obesity, vol. 37, no. 9, pp. 1211-1220. https://doi.org/10.1038/ijo.2012.215

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abstract = "Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P",

keywords = "gene-diet interactions, Low-density lipoprotein receptor-related protein 1, saturated fatty acids, SNPs",

author = "Smith, {C. E.} and J. Ngwa and T. Tanaka and Q. Qi and Wojczynski, {M. K.} and Lemaitre, {R. N.} and Anderson, {J. S.} and A. Manichaikul and V. Mikkil{\"a} and {Van Rooij}, {F. J A} and Z. Ye and S. Bandinelli and Frazier-Wood, {A. C.} and Houston, {D. K.} and F. Hu and C. Langenberg and McKeown, {N. M.} and D. Mozaffarian and North, {K. E.} and J. Viikari and Zillikens, {M. C.} and L. Djouss{\'e} and A. Hofman and M. K{\"a}h{\"o}nen and Kabagambe, {E. K.} and Loos, {R. J F} and Saylor, {G. B.} and Forouhi, {N. G.} and Y. Liu and Mukamal, {K. J.} and Chen, {Y. Di} and Tsai, {M. Y.} and Uitterlinden, {A. G.} and O. Raitakari and {Van Duijn}, {C. M.} and Arnett, {D. K.} and Borecki, {I. B.} and Cupples, {L. A.} and L. Ferrucci and Kritchevsky, {S. B.} and T. Lehtim{\"a}ki and Lu Qi and Rotter, {J. I.} and Siscovick, {D. S.} and Wareham, {N. J.} and Witteman, {J. C M} and Ordov{\'a}s, {J. M.} and Nettleton, {J. A.}",

year = "2013",

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language = "English (US)",

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T1 - Lipoprotein receptor-related protein 1 variants and dietary fatty acids

T2 - Meta-analysis of European origin and African American studies

AU - Smith, C. E.

AU - Ngwa, J.

AU - Tanaka, T.

AU - Qi, Q.

AU - Wojczynski, M. K.

AU - Lemaitre, R. N.

AU - Anderson, J. S.

AU - Manichaikul, A.

AU - Mikkilä, V.

AU - Van Rooij, F. J A

AU - Ye, Z.

AU - Bandinelli, S.

AU - Frazier-Wood, A. C.

AU - Houston, D. K.

AU - Hu, F.

AU - Langenberg, C.

AU - McKeown, N. M.

AU - Mozaffarian, D.

AU - North, K. E.

AU - Viikari, J.

AU - Zillikens, M. C.

AU - Djoussé, L.

AU - Hofman, A.

AU - Kähönen, M.

AU - Kabagambe, E. K.

AU - Loos, R. J F

AU - Saylor, G. B.

AU - Forouhi, N. G.

AU - Liu, Y.

AU - Mukamal, K. J.

AU - Chen, Y. Di

AU - Tsai, M. Y.

AU - Uitterlinden, A. G.

AU - Raitakari, O.

AU - Van Duijn, C. M.

AU - Arnett, D. K.

AU - Borecki, I. B.

AU - Cupples, L. A.

AU - Ferrucci, L.

AU - Kritchevsky, S. B.

AU - Lehtimäki, T.

AU - Qi, Lu

AU - Rotter, J. I.

AU - Siscovick, D. S.

AU - Wareham, N. J.

AU - Witteman, J. C M

AU - Ordovás, J. M.

AU - Nettleton, J. A.

PY - 2013/9

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N2 - Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P

AB - Objective:Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in adipose and the hypothalamus. Evidence for a role of LRP1 in adiposity is accumulating from animal and in vitro models, but data from human studies are limited. The study objectives were to evaluate (i) relationships between LRP1 genotype and anthropometric traits, and (ii) whether these relationships were modified by dietary fatty acids.Design and methods:We conducted race/ethnic-specific meta-analyses using data from 14 studies of US and European whites and 4 of African Americans to evaluate associations of dietary fatty acids and LRP1 genotypes with body mass index (BMI), waist circumference and hip circumference, as well as interactions between dietary fatty acids and LRP1 genotypes. Seven single-nucleotide polymorphisms (SNPs) of LRP1 were evaluated in whites (N up to 42 000) and twelve SNPs in African Americans (N up to 5800).Results:After adjustment for age, sex and population substructure if relevant, for each one unit greater intake of percentage of energy from saturated fat (SFA), BMI was 0.104 kg m -2 greater, waist was 0.305 cm larger and hip was 0.168 cm larger (all P

KW - gene-diet interactions

KW - Low-density lipoprotein receptor-related protein 1

KW - saturated fatty acids

KW - SNPs

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JO - International Journal of Obesity

JF - International Journal of Obesity

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ER -

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies

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Keywords

ASJC Scopus subject areas

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