Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy

M. Braga-Basaria, D. C. Muller, Michael A Carducci, Adrian S Dobs, S. Basaria

Research output: Contribution to journalArticle

Abstract

Sex steroids are known to modulate serum lipoproteins. Studies have suggested that serum testosterone levels are associated with a beneficial lipid profile. Androgen deprivation therapy (ADT) is employed in the treatment of recurrent and metastatic prostate cancer (PCa), resulting in profound hypogonadism. As male hypogonadism unfavorably influences lipid profile and men with PCa have high cardiovascular mortality, we evaluated the effects of long-term ADT on fasting lipids. This Cross-sectional study was conducted in a university-based research institution. We evaluated 44 men, 16 undergoing ADT for at least 12 months before the study (ADT group), 14 age-matched eugonadal men with non-metastatic PCa who were status post prostatectomy and/or radiotherapy and not on ADT (non-ADT group) and 14 age-matched eugonadal controls (Control group). None of the men had known history of diabetes or dyslipidemia. Mean age was similar in the three groups (P=0.37). Serum total (P

Original languageEnglish (US)
Pages (from-to)494-498
Number of pages5
JournalInternational journal of impotence research : official journal of the International Society for Impotence Research
Volume18
Issue number5
DOIs
StatePublished - Sep 5 2006

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Androgens
Lipoproteins
Prostatic Neoplasms
Group Psychotherapy
Lipids
Age Groups
Serum
Eunuchism
Therapeutics
Hypogonadism
Prostatectomy
Dyslipidemias
Testosterone
Fasting
Radiotherapy
Cross-Sectional Studies
Steroids
Control Groups
Mortality
Research

Keywords

  • Androgen deprivation therapy
  • Cardiovascular disease
  • Hyperlipidemia
  • Hypogonadism

ASJC Scopus subject areas

  • Urology

Cite this

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