TY - JOUR
T1 - Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis
AU - MacKey, Rachel H.
AU - Mora, Samia
AU - Bertoni, Alain G.
AU - Wassel, Christina L.
AU - Carnethon, Mercedes R.
AU - Sibley, Christopher T.
AU - Goff, David C.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - OBJECTIVE In the Multi-Ethnic Study of Atherosclerosis (MESA), we evaluated associations of baseline levels of a lipoprotein-based insulin resistance (IR) index (LP-IR), IR-related lipoprotein particles, mean particle sizes, and lipids, with incident type 2 diabetes, independent of confounders, glucose, insulin, and HOMA-IR. RESEARCH DESIGN AND METHODS Among 5,314 adults aged 45-84 years without baseline diabetes or cardiovascular disease, 656 cases of diabetes were identified during a mean follow-up of 7.7 years. Lipoprotein particle concentrations, size, and LP-IR were determined by nuclear magnetic resonance spectroscopy of stored baseline plasma. Potential effect modification, by race/ethnicity, sex, baseline use of lipid-lowering medications or hormone therapy, or glucose strata (
AB - OBJECTIVE In the Multi-Ethnic Study of Atherosclerosis (MESA), we evaluated associations of baseline levels of a lipoprotein-based insulin resistance (IR) index (LP-IR), IR-related lipoprotein particles, mean particle sizes, and lipids, with incident type 2 diabetes, independent of confounders, glucose, insulin, and HOMA-IR. RESEARCH DESIGN AND METHODS Among 5,314 adults aged 45-84 years without baseline diabetes or cardiovascular disease, 656 cases of diabetes were identified during a mean follow-up of 7.7 years. Lipoprotein particle concentrations, size, and LP-IR were determined by nuclear magnetic resonance spectroscopy of stored baseline plasma. Potential effect modification, by race/ethnicity, sex, baseline use of lipid-lowering medications or hormone therapy, or glucose strata (
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U2 - 10.2337/dc14-0645
DO - 10.2337/dc14-0645
M3 - Article
C2 - 25592196
AN - SCOPUS:84962135661
SN - 0149-5992
VL - 38
SP - 628
EP - 636
JO - Diabetes Care
JF - Diabetes Care
IS - 4
ER -