Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis

Rachel H. MacKey, Samia Mora, Alain G. Bertoni, Christina L. Wassel, Mercedes R. Carnethon, Christopher T. Sibley, David C. Goff

Research output: Contribution to journalArticle

Abstract

OBJECTIVE In the Multi-Ethnic Study of Atherosclerosis (MESA), we evaluated associations of baseline levels of a lipoprotein-based insulin resistance (IR) index (LP-IR), IR-related lipoprotein particles, mean particle sizes, and lipids, with incident type 2 diabetes, independent of confounders, glucose, insulin, and HOMA-IR. RESEARCH DESIGN AND METHODS Among 5,314 adults aged 45-84 years without baseline diabetes or cardiovascular disease, 656 cases of diabetes were identified during a mean follow-up of 7.7 years. Lipoprotein particle concentrations, size, and LP-IR were determined by nuclear magnetic resonance spectroscopy of stored baseline plasma. Potential effect modification, by race/ethnicity, sex, baseline use of lipid-lowering medications or hormone therapy, or glucose strata (

Original languageEnglish (US)
Pages (from-to)628-636
Number of pages9
JournalDiabetes Care
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

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Type 2 Diabetes Mellitus
Lipoproteins
Insulin Resistance
Atherosclerosis
Particle Size
Lipids
Glucose
Research Design
Cardiovascular Diseases
Magnetic Resonance Spectroscopy
Hormones
Insulin
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

MacKey, R. H., Mora, S., Bertoni, A. G., Wassel, C. L., Carnethon, M. R., Sibley, C. T., & Goff, D. C. (2015). Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis. Diabetes Care, 38(4), 628-636. https://doi.org/10.2337/dc14-0645

Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis. / MacKey, Rachel H.; Mora, Samia; Bertoni, Alain G.; Wassel, Christina L.; Carnethon, Mercedes R.; Sibley, Christopher T.; Goff, David C.

In: Diabetes Care, Vol. 38, No. 4, 01.04.2015, p. 628-636.

Research output: Contribution to journalArticle

MacKey, RH, Mora, S, Bertoni, AG, Wassel, CL, Carnethon, MR, Sibley, CT & Goff, DC 2015, 'Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis', Diabetes Care, vol. 38, no. 4, pp. 628-636. https://doi.org/10.2337/dc14-0645
MacKey RH, Mora S, Bertoni AG, Wassel CL, Carnethon MR, Sibley CT et al. Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis. Diabetes Care. 2015 Apr 1;38(4):628-636. https://doi.org/10.2337/dc14-0645
MacKey, Rachel H. ; Mora, Samia ; Bertoni, Alain G. ; Wassel, Christina L. ; Carnethon, Mercedes R. ; Sibley, Christopher T. ; Goff, David C. / Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis. In: Diabetes Care. 2015 ; Vol. 38, No. 4. pp. 628-636.
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