Lipoprotein particles and incident type 2 diabetes in the multi- ethnic study of atherosclerosis

Rachel H. MacKey, Samia Mora, Alain G. Bertoni, Christina L. Wassel, Mercedes R. Carnethon, Christopher T. Sibley, David C. Goff

Research output: Contribution to journalArticlepeer-review


OBJECTIVE In the Multi-Ethnic Study of Atherosclerosis (MESA), we evaluated associations of baseline levels of a lipoprotein-based insulin resistance (IR) index (LP-IR), IR-related lipoprotein particles, mean particle sizes, and lipids, with incident type 2 diabetes, independent of confounders, glucose, insulin, and HOMA-IR. RESEARCH DESIGN AND METHODS Among 5,314 adults aged 45-84 years without baseline diabetes or cardiovascular disease, 656 cases of diabetes were identified during a mean follow-up of 7.7 years. Lipoprotein particle concentrations, size, and LP-IR were determined by nuclear magnetic resonance spectroscopy of stored baseline plasma. Potential effect modification, by race/ethnicity, sex, baseline use of lipid-lowering medications or hormone therapy, or glucose strata (

Original languageEnglish (US)
Pages (from-to)628-636
Number of pages9
JournalDiabetes Care
Issue number4
StatePublished - Apr 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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