Lipoprotein and oxygen transport alterations in passive smoking preadolescent children: The MCV twin study

William B. Moskowitz, Michael Mosteller, Richard M. Schieken, Rodrigo Bossano, John K. Hewitt, Joann N Bodurtha, Jere P. Segrest

Research output: Contribution to journalArticle

Abstract

We investigated the cardiovascular effects of lifelong passive cigarette smoke exposure in preadolescent children and examined the following questions: 1) Is systemic oxygen transport altered? 2) Are coronary heart disease risk factors adversely affected? We recruited 216 families from the MCV Twin Study; 105 had at least one smoking parent. Serum thiocyanate and cotinine levels were used as measures of smoke exposure in the children and thiocyanate was proportional to the number of parental cigarettes smoked each day (p=0.0001). Paternal smoking had no effect on these measures. Whole blood 2,3-diphosphoglycerate was higher in smoke-exposed than unexposed children (p2 subfraction was reduced in passive smoking boys, while the HDL3 subfraction was reduced in passive smoking girls. Significant adverse alterations in systemic oxygen transport and lipoprotein profiles are already present in preadolescent children exposed to long-term passive cigarette smoke, primarily from maternal smoke. Children with long-term exposure to passive smoke may be at elevated risk for the development of premature coronary heart disease.

Original languageEnglish (US)
Pages (from-to)586-592
Number of pages7
JournalCirculation
Volume81
Issue number2
StatePublished - Feb 1990
Externally publishedYes

Fingerprint

Tobacco Smoke Pollution
Twin Studies
Smoke
Lipoproteins
Oxygen
Tobacco Products
Coronary Disease
Smoking
2,3-Diphosphoglycerate
Cotinine
Mothers
Serum

Keywords

  • Atherosclerosis
  • Cardiovascular disease, prevention
  • High density lipoprotein cholesterol
  • Smoking, passive

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Moskowitz, W. B., Mosteller, M., Schieken, R. M., Bossano, R., Hewitt, J. K., Bodurtha, J. N., & Segrest, J. P. (1990). Lipoprotein and oxygen transport alterations in passive smoking preadolescent children: The MCV twin study. Circulation, 81(2), 586-592.

Lipoprotein and oxygen transport alterations in passive smoking preadolescent children : The MCV twin study. / Moskowitz, William B.; Mosteller, Michael; Schieken, Richard M.; Bossano, Rodrigo; Hewitt, John K.; Bodurtha, Joann N; Segrest, Jere P.

In: Circulation, Vol. 81, No. 2, 02.1990, p. 586-592.

Research output: Contribution to journalArticle

Moskowitz, WB, Mosteller, M, Schieken, RM, Bossano, R, Hewitt, JK, Bodurtha, JN & Segrest, JP 1990, 'Lipoprotein and oxygen transport alterations in passive smoking preadolescent children: The MCV twin study', Circulation, vol. 81, no. 2, pp. 586-592.
Moskowitz WB, Mosteller M, Schieken RM, Bossano R, Hewitt JK, Bodurtha JN et al. Lipoprotein and oxygen transport alterations in passive smoking preadolescent children: The MCV twin study. Circulation. 1990 Feb;81(2):586-592.
Moskowitz, William B. ; Mosteller, Michael ; Schieken, Richard M. ; Bossano, Rodrigo ; Hewitt, John K. ; Bodurtha, Joann N ; Segrest, Jere P. / Lipoprotein and oxygen transport alterations in passive smoking preadolescent children : The MCV twin study. In: Circulation. 1990 ; Vol. 81, No. 2. pp. 586-592.
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