Lipid Peroxidation and Depressed Mood in Community-Dwelling Older Men and Women

Yuri Milaneschi, Matteo Cesari, Eleanor M. Simonsick, Nicole Vogelzangs, Alka M. Kanaya, Kristine Yaffe, Paola Patrignani, Andrea Metti, Stephen B. Kritchevsky, Marco Pahor, Luigi Ferrucci, Brenda W.J.H. Penninx

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27 Scopus citations


It has been hypothesized that cellular damage caused by oxidative stress is associated with late-life depression but epidemiological evidence is limited. In the present study we evaluated the association between urinary 8-iso-prostaglandin F (8-iso-PGF), a biomarker of lipid peroxidation, and depressed mood in a large sample of community-dwelling older adults. Participants were selected from the Health, Aging and Body Composition study, a community-based longitudinal study of older persons (aged 70-79 years). The present analyses was based on a subsample of 1027 men and 948 women free of mobility disability. Urinary concentration of 8-iso-PGF was measured by radioimmunoassay methods and adjusted for urinary creatinine. Depressed mood was defined as a score greater than 5 on the 15-item Geriatric Depression Scale and/or use of antidepressant medications. Depressed mood was present in 3.0% of men and 5.5% of women. Depressed men presented higher urinary concentrations of 8-iso-PGF than non-depressed men even after adjustment for multiple sociodemographic, lifestyle and health factors (p = 0.03, Cohen's d = 0.30). This association was not present in women (depressed status-by-sex interaction p = 0.04). Our study showed that oxidative damage may be linked to depression in older men from a large sample of the general population. Further studies are needed to explore whether the modulation of oxidative stress may break down the link between late-life depression and its deleterious health consequences.

Original languageEnglish (US)
Article numbere65406
JournalPloS one
Issue number6
StatePublished - Jun 11 2013
Externally publishedYes

ASJC Scopus subject areas

  • General


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