Lipid metabolism and accumulation in perfused rabbit aorta

James C.A. Fuchs; Sewell H. Dixon; Per Otto Hagen

doi:10.1016/0022-4804(79)90057-X

Lipid metabolism and accumulation in perfused rabbit aorta

James C.A. Fuchs, Sewell H. Dixon, Per Otto Hagen

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A model is described for study of lipid accumulation and metabolism in an in situ segment of perfused aorta. This technic was used in 36 normal rabbits to determine the influence of pressure on the uptake and synthesis of vascular lipids. Accumulation of labeled serum cholesterol and oleic acid was found to be a function of the mean perfusion pressure. Increased pressure also resulted in a shift in the incorporation of the labeled acetate from the triglyceride to the phospholipid fraction of the arterial lipids.

Original language	English (US)
Pages (from-to)	611-617
Number of pages	7
Journal	Journal of Surgical Research
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/0022-4804(79)90057-X
State	Published - Jun 1979

ASJC Scopus subject areas

Surgery

Access to Document

10.1016/0022-4804(79)90057-X

Cite this

@article{d1c9ca43a9cd490b95cd94fe1fd2e830,

title = "Lipid metabolism and accumulation in perfused rabbit aorta",

abstract = "A model is described for study of lipid accumulation and metabolism in an in situ segment of perfused aorta. This technic was used in 36 normal rabbits to determine the influence of pressure on the uptake and synthesis of vascular lipids. Accumulation of labeled serum cholesterol and oleic acid was found to be a function of the mean perfusion pressure. Increased pressure also resulted in a shift in the incorporation of the labeled acetate from the triglyceride to the phospholipid fraction of the arterial lipids.",

author = "Fuchs, {James C.A.} and Dixon, {Sewell H.} and Hagen, {Per Otto}",

note = "Funding Information: {\textquoteright} Supported by USPHS Grants HL-15448 and GM-01709. {\textquoteright} Present address: 1016P rofessional Village, Greensboro, N. C. 27401. 3 To whom all correspondence should be sent: P.O. Box 3473, DUMC, Durham, N. C. 27710.",

year = "1979",

month = jun,

doi = "10.1016/0022-4804(79)90057-X",

language = "English (US)",

volume = "26",

pages = "611--617",

journal = "Journal of Surgical Research",

issn = "0022-4804",

publisher = "Academic Press Inc.",

number = "6",

}

TY - JOUR

T1 - Lipid metabolism and accumulation in perfused rabbit aorta

AU - Fuchs, James C.A.

AU - Dixon, Sewell H.

AU - Hagen, Per Otto

N1 - Funding Information: ’ Supported by USPHS Grants HL-15448 and GM-01709. ’ Present address: 1016P rofessional Village, Greensboro, N. C. 27401. 3 To whom all correspondence should be sent: P.O. Box 3473, DUMC, Durham, N. C. 27710.

PY - 1979/6

Y1 - 1979/6

N2 - A model is described for study of lipid accumulation and metabolism in an in situ segment of perfused aorta. This technic was used in 36 normal rabbits to determine the influence of pressure on the uptake and synthesis of vascular lipids. Accumulation of labeled serum cholesterol and oleic acid was found to be a function of the mean perfusion pressure. Increased pressure also resulted in a shift in the incorporation of the labeled acetate from the triglyceride to the phospholipid fraction of the arterial lipids.

AB - A model is described for study of lipid accumulation and metabolism in an in situ segment of perfused aorta. This technic was used in 36 normal rabbits to determine the influence of pressure on the uptake and synthesis of vascular lipids. Accumulation of labeled serum cholesterol and oleic acid was found to be a function of the mean perfusion pressure. Increased pressure also resulted in a shift in the incorporation of the labeled acetate from the triglyceride to the phospholipid fraction of the arterial lipids.

UR - http://www.scopus.com/inward/record.url?scp=0018397747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018397747&partnerID=8YFLogxK

U2 - 10.1016/0022-4804(79)90057-X

DO - 10.1016/0022-4804(79)90057-X

M3 - Article

C2 - 449298

AN - SCOPUS:0018397747

SN - 0022-4804

VL - 26

SP - 611

EP - 617

JO - Journal of Surgical Research

JF - Journal of Surgical Research

IS - 6

ER -

Lipid metabolism and accumulation in perfused rabbit aorta

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this