Lipid metabolism and accumulation in perfused rabbit aorta

James C A Fuchs, Sewell H. Dixon, Per Otto Hagen

Research output: Contribution to journalArticle

Abstract

A model is described for study of lipid accumulation and metabolism in an in situ segment of perfused aorta. This technic was used in 36 normal rabbits to determine the influence of pressure on the uptake and synthesis of vascular lipids. Accumulation of labeled serum cholesterol and oleic acid was found to be a function of the mean perfusion pressure. Increased pressure also resulted in a shift in the incorporation of the labeled acetate from the triglyceride to the phospholipid fraction of the arterial lipids.

Original languageEnglish (US)
Pages (from-to)611-617
Number of pages7
JournalJournal of Surgical Research
Volume26
Issue number6
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Lipid Metabolism
Aorta
Rabbits
Pressure
Lipids
Oleic Acid
Blood Vessels
Phospholipids
Triglycerides
Acetates
Perfusion
Cholesterol
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Lipid metabolism and accumulation in perfused rabbit aorta. / Fuchs, James C A; Dixon, Sewell H.; Hagen, Per Otto.

In: Journal of Surgical Research, Vol. 26, No. 6, 1979, p. 611-617.

Research output: Contribution to journalArticle

Fuchs, James C A ; Dixon, Sewell H. ; Hagen, Per Otto. / Lipid metabolism and accumulation in perfused rabbit aorta. In: Journal of Surgical Research. 1979 ; Vol. 26, No. 6. pp. 611-617.
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