A model is described for study of lipid accumulation and metabolism in an in situ segment of perfused aorta. This technic was used in 36 normal rabbits to determine the influence of pressure on the uptake and synthesis of vascular lipids. Accumulation of labeled serum cholesterol and oleic acid was found to be a function of the mean perfusion pressure. Increased pressure also resulted in a shift in the incorporation of the labeled acetate from the triglyceride to the phospholipid fraction of the arterial lipids.
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