Lipid metabolism and accumulation in perfused rabbit aorta

James C.A. Fuchs, Sewell H. Dixon, Per Otto Hagen

Research output: Contribution to journalArticlepeer-review


A model is described for study of lipid accumulation and metabolism in an in situ segment of perfused aorta. This technic was used in 36 normal rabbits to determine the influence of pressure on the uptake and synthesis of vascular lipids. Accumulation of labeled serum cholesterol and oleic acid was found to be a function of the mean perfusion pressure. Increased pressure also resulted in a shift in the incorporation of the labeled acetate from the triglyceride to the phospholipid fraction of the arterial lipids.

Original languageEnglish (US)
Pages (from-to)611-617
Number of pages7
JournalJournal of Surgical Research
Issue number6
StatePublished - Jun 1979

ASJC Scopus subject areas

  • Surgery

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