Lipid disorders: Justification of methods and goals of treatment

Joel B. Braunstein, Alan Cheng, Gregory Cohn, Monica Aggarwal, Caitlin M. Nass, Roger S. Blumenthal

Research output: Contribution to journalReview article

Abstract

Dyslipidemia is a major risk factor for coronary heart disease (CHD). While some uncertainty exists about the clinical significance of improving high-density lipoprotein cholesterol and triglyceride levels, large primary- and secondary-prevention studies aimed at lowering low-density lipoprotein cholesterol levels with statins have convincingly reduced CHD events and total mortality. Despite the strong clinical evidence and widely publicized treatment guidelines, many hyperlipidemic patients receive inadequate lipid-lowering treatment. This failure to achieve clinical treatment goals may be due to poor physician adherence to treatment guidelines, patient noncompliance, and the presence of concomitant medical conditions that modify typical hyperlipidemia management. This review considers the challenges and available strategies to optimize lipid management in patients at risk for CHD.

Original languageEnglish (US)
Pages (from-to)979-988
Number of pages10
JournalCHEST
Volume120
Issue number3
DOIs
StatePublished - Jan 1 2001

    Fingerprint

Keywords

  • Cardiovascular risk factors
  • Coronary heart disease
  • Dyslipidemia
  • Hypercholesterolemia
  • Lipid-lowering agents
  • Statins

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Braunstein, J. B., Cheng, A., Cohn, G., Aggarwal, M., Nass, C. M., & Blumenthal, R. S. (2001). Lipid disorders: Justification of methods and goals of treatment. CHEST, 120(3), 979-988. https://doi.org/10.1378/chest.120.3.979