Lipid concentrations and couple fecundity: The LIFE study

Enrique F. Schisterman, Sunni L. Mumford, Richard W. Browne, Dana Boyd Barr, Zhen Chen, Germaine M. Buck Louis

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Context: A role of lipids in human fecundity is hypothesized as cholesterol is the main substrate for steroid synthesis and has also been shown to affect the hormonal milieu and steroidogenesis in both men and women. Objective: The objective of the study was to evaluate the association between male and female serum lipid concentrations and time to pregnancy (TTP). Design/Setting: A population-based prospective cohort study recruiting couples from 16 counties in Michigan and Texas (2005-2009) using sampling frameworks allowing for identification of couples planning pregnancy in the near future. Participants: Five hundred one couples desiring pregnancy and discontinuing contraception were followed up for 12 months or until a human chorionic gonadotropin pregnancy was detected. Main Outcome and Measures: Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated after adjusting for age, body mass index, race, and education in relationship to female, male, and joint couple lipid concentrations. Results: Serum free cholesterol levels were higher on average among male and female partners of couples who did not became pregnant during the study follow-up (female, P

Original languageEnglish (US)
Pages (from-to)2786-2794
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Issue number8
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism


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