Linking cilia to Wnts

Gregory G. Germino

doi:10.1038/ng0505-455

Linking cilia to Wnts

Gregory G. Germino

School of Medicine

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Inversin is a component of a poorly understood cilia-based mechanism responsible for specifying the left-right axis during development and for maintaining normal kidney architecture throughout life. A new study now suggests that inversin might act as a flow-regulated molecular switch between canonical and noncanonical Wnt pathways, providing insights into the mechanisms underlying cilia-based signaling processes.

Original language	English (US)
Pages (from-to)	455-457
Number of pages	3
Journal	Nature Genetics
Volume	37
Issue number	5
DOIs	https://doi.org/10.1038/ng0505-455
State	Published - May 2005

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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10.1038/ng0505-455

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abstract = "Inversin is a component of a poorly understood cilia-based mechanism responsible for specifying the left-right axis during development and for maintaining normal kidney architecture throughout life. A new study now suggests that inversin might act as a flow-regulated molecular switch between canonical and noncanonical Wnt pathways, providing insights into the mechanisms underlying cilia-based signaling processes.",

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Linking cilia to Wnts

Abstract

ASJC Scopus subject areas

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