Abstract
Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1619-1622 |
| Number of pages | 4 |
| Journal | Journal of Clinical Investigation |
| Volume | 118 |
| Issue number | 5 |
| DOIs |
|
| State | Published - May 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Linking adiponectin to proteinuria. / Ahima, Rexford S.
In: Journal of Clinical Investigation, Vol. 118, No. 5, 01.05.2008, p. 1619-1622.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Linking adiponectin to proteinuria
AU - Ahima, Rexford S
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.
AB - Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.
UR - http://www.scopus.com/inward/record.url?scp=43049097496&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43049097496&partnerID=8YFLogxK
U2 - 10.1172/JCI35655
DO - 10.1172/JCI35655
M3 - Comment/debate
C2 - 18431507
AN - SCOPUS:43049097496
VL - 118
SP - 1619
EP - 1622
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 5
ER -