Linking adiponectin to proteinuria

Research output: Contribution to journalComment/debate

Abstract

Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.

Original languageEnglish (US)
Pages (from-to)1619-1622
Number of pages4
JournalJournal of Clinical Investigation
Volume118
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Adiponectin
Proteinuria
Albuminuria
Kidney Glomerulus
Podocytes
AMP-Activated Protein Kinases
Kidney Diseases
African Americans
Albumins
Oxidative Stress
Obesity
Biomarkers
Hormones
Hypertension
Kidney
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Linking adiponectin to proteinuria. / Ahima, Rexford S.

In: Journal of Clinical Investigation, Vol. 118, No. 5, 01.05.2008, p. 1619-1622.

Research output: Contribution to journalComment/debate

@article{c4deb547cd50444ca0363012c27d8bfc,
title = "Linking adiponectin to proteinuria",
abstract = "Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.",
author = "Ahima, {Rexford S}",
year = "2008",
month = "5",
day = "1",
doi = "10.1172/JCI35655",
language = "English (US)",
volume = "118",
pages = "1619--1622",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "5",

}

TY - JOUR

T1 - Linking adiponectin to proteinuria

AU - Ahima, Rexford S

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.

AB - Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.

UR - http://www.scopus.com/inward/record.url?scp=43049097496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43049097496&partnerID=8YFLogxK

U2 - 10.1172/JCI35655

DO - 10.1172/JCI35655

M3 - Comment/debate

C2 - 18431507

AN - SCOPUS:43049097496

VL - 118

SP - 1619

EP - 1622

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 5

ER -