Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population

Shengfeng Liu, Haiying Wang, Ming Song, Luxian Lv, Yue Cui, Yong Liu, Lingzhong Fan, Nianming Zuo, Kaibin Xu, Yuhui Du, Qingbao Yu, Na Luo, Shile Qi, Jian Yang, Sangma Xie, Jian Li, Jun Chen, Yunchun Chen, Huaning Wang, Hua Guo & 12 others Ping Wan, Yongfeng Yang, Peng Li, Lin Lu, Hao Yan, Jun Yan, Huiling Wang, Hongxing Zhang, Dai Zhang, Vince Daniel Calhoun, Tianzi Jiang, Jing Sui

Research output: Contribution to journalArticle

Abstract

Multimodal fusion has been regarded as a promising tool to discover covarying patterns of multiple imaging types impaired in brain diseases, such as schizophrenia (SZ). In this article, we aim to investigate the covarying abnormalities underlying SZ in a large Chinese Han population (307 SZs, 298 healthy controls [HCs]). Four types of magnetic resonance imaging (MRI) features, including regional homogeneity (ReHo) from resting-state functional MRI, gray matter volume (GM) from structural MRI, fractional anisotropy (FA) from diffusion MRI, and functional network connectivity (FNC) resulted from group independent component analysis, were jointly analyzed by a data-driven multivariate fusion method. Results suggest that a widely distributed network disruption appears in SZ patients, with synchronous changes in both functional and structural regions, especially the basal ganglia network, salience network (SAN), and the frontoparietal network. Such a multimodal coalteration was also replicated in another independent Chinese sample (40 SZs, 66 HCs). Our results on auditory verbal hallucination (AVH) also provide evidence for the hypothesis that prefrontal hypoactivation and temporal hyperactivation in SZ may lead to failure of executive control and inhibition, which is relevant to AVH. In addition, impaired working memory performance was found associated with GM reduction and FA decrease in SZ in prefrontal and superior temporal area, in both discovery and replication datasets. In summary, by leveraging multiple imaging and clinical information into one framework to observe brain in multiple views, we can integrate multiple inferences about SZ from large-scale population and offer unique perspectives regarding the missing links between the brain function and structure that may not be achieved by separate unimodal analyses.

Original languageEnglish (US)
Pages (from-to)436-449
Number of pages14
JournalSchizophrenia bulletin
Volume45
Issue number2
DOIs
StatePublished - Mar 7 2019
Externally publishedYes

Fingerprint

Schizophrenia
Brain
Population
Hallucinations
Anisotropy
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
Executive Function
Brain Diseases
Basal Ganglia
Short-Term Memory
Gray Matter

Keywords

  • auditory hallucination
  • diffusion MRI
  • functional network connectivity (FNC)
  • MCCA + jICA
  • multimodal fusion
  • resting-state fMRI
  • schizophrenia
  • structural MRI

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population. / Liu, Shengfeng; Wang, Haiying; Song, Ming; Lv, Luxian; Cui, Yue; Liu, Yong; Fan, Lingzhong; Zuo, Nianming; Xu, Kaibin; Du, Yuhui; Yu, Qingbao; Luo, Na; Qi, Shile; Yang, Jian; Xie, Sangma; Li, Jian; Chen, Jun; Chen, Yunchun; Wang, Huaning; Guo, Hua; Wan, Ping; Yang, Yongfeng; Li, Peng; Lu, Lin; Yan, Hao; Yan, Jun; Wang, Huiling; Zhang, Hongxing; Zhang, Dai; Calhoun, Vince Daniel; Jiang, Tianzi; Sui, Jing.

In: Schizophrenia bulletin, Vol. 45, No. 2, 07.03.2019, p. 436-449.

Research output: Contribution to journalArticle

Liu, S, Wang, H, Song, M, Lv, L, Cui, Y, Liu, Y, Fan, L, Zuo, N, Xu, K, Du, Y, Yu, Q, Luo, N, Qi, S, Yang, J, Xie, S, Li, J, Chen, J, Chen, Y, Wang, H, Guo, H, Wan, P, Yang, Y, Li, P, Lu, L, Yan, H, Yan, J, Wang, H, Zhang, H, Zhang, D, Calhoun, VD, Jiang, T & Sui, J 2019, 'Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population', Schizophrenia bulletin, vol. 45, no. 2, pp. 436-449. https://doi.org/10.1093/schbul/sby045
Liu, Shengfeng ; Wang, Haiying ; Song, Ming ; Lv, Luxian ; Cui, Yue ; Liu, Yong ; Fan, Lingzhong ; Zuo, Nianming ; Xu, Kaibin ; Du, Yuhui ; Yu, Qingbao ; Luo, Na ; Qi, Shile ; Yang, Jian ; Xie, Sangma ; Li, Jian ; Chen, Jun ; Chen, Yunchun ; Wang, Huaning ; Guo, Hua ; Wan, Ping ; Yang, Yongfeng ; Li, Peng ; Lu, Lin ; Yan, Hao ; Yan, Jun ; Wang, Huiling ; Zhang, Hongxing ; Zhang, Dai ; Calhoun, Vince Daniel ; Jiang, Tianzi ; Sui, Jing. / Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population. In: Schizophrenia bulletin. 2019 ; Vol. 45, No. 2. pp. 436-449.
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AU - Wang, Haiying

AU - Song, Ming

AU - Lv, Luxian

AU - Cui, Yue

AU - Liu, Yong

AU - Fan, Lingzhong

AU - Zuo, Nianming

AU - Xu, Kaibin

AU - Du, Yuhui

AU - Yu, Qingbao

AU - Luo, Na

AU - Qi, Shile

AU - Yang, Jian

AU - Xie, Sangma

AU - Li, Jian

AU - Chen, Jun

AU - Chen, Yunchun

AU - Wang, Huaning

AU - Guo, Hua

AU - Wan, Ping

AU - Yang, Yongfeng

AU - Li, Peng

AU - Lu, Lin

AU - Yan, Hao

AU - Yan, Jun

AU - Wang, Huiling

AU - Zhang, Hongxing

AU - Zhang, Dai

AU - Calhoun, Vince Daniel

AU - Jiang, Tianzi

AU - Sui, Jing

PY - 2019/3/7

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