Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations

Kathleen C. Barnes, John D. Neely, David L. Duffy, Linda R. Freidhoff, Daniel R. Breazeale, Carsten Schou, Raana P. Naidu, Paul N. Levett, Beatrice Renault, Raju Kucherlapati, Sebastiano Iozzino, Eva Ehrlich, Terri H. Beaty, David G. Marsh

Research output: Contribution to journalArticle

Abstract

To identify genes potentially relevant in atopic asthma, we analyzed markers in chromosome 12q15-q24.1 for linkage to asthma and total serum IgE concentration. Sib-pair analyses of 10 markers in 345 full- and 219 half-sib pairs from 29 multiplex Afro-Caribbean families provided evidence for linkage to this region for both asthma and total serum IgE. Certain alleles at these loci showed significant evidence of transmission disequilibrium with both asthma and high IgE. Using 6 of these markers and 11 additional markers, evidence for linkage of total IgE to 12q was also found in 12 Caucasian Amish kindreds (24 nuclear families) by both sibpair and transmission disequilibrium analyses. These findings suggest that the 12q15-q24.1 region may contain a gene(s) controlling asthma and the associated 'high total IgE' trait.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalGenomics
Volume37
Issue number1
DOIs
StatePublished - Oct 1 1996

ASJC Scopus subject areas

  • Genetics

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    Barnes, K. C., Neely, J. D., Duffy, D. L., Freidhoff, L. R., Breazeale, D. R., Schou, C., Naidu, R. P., Levett, P. N., Renault, B., Kucherlapati, R., Iozzino, S., Ehrlich, E., Beaty, T. H., & Marsh, D. G. (1996). Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations. Genomics, 37(1), 41-50. https://doi.org/10.1006/geno.1996.0518