@article{fa0c793f2953469382c267f8207d53f0,
title = "Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations",
abstract = "To identify genes potentially relevant in atopic asthma, we analyzed markers in chromosome 12q15-q24.1 for linkage to asthma and total serum IgE concentration. Sib-pair analyses of 10 markers in 345 full- and 219 half-sib pairs from 29 multiplex Afro-Caribbean families provided evidence for linkage to this region for both asthma and total serum IgE. Certain alleles at these loci showed significant evidence of transmission disequilibrium with both asthma and high IgE. Using 6 of these markers and 11 additional markers, evidence for linkage of total IgE to 12q was also found in 12 Caucasian Amish kindreds (24 nuclear families) by both sibpair and transmission disequilibrium analyses. These findings suggest that the 12q15-q24.1 region may contain a gene(s) controlling asthma and the associated 'high total IgE' trait.",
author = "Barnes, {Kathleen C.} and Neely, {John D.} and Duffy, {David L.} and Freidhoff, {Linda R.} and Breazeale, {Daniel R.} and Carsten Schou and Naidu, {Raana P.} and Levett, {Paul N.} and Beatrice Renault and Raju Kucherlapati and Sebastiano Iozzino and Eva Ehrlich and Beaty, {Terri H.} and Marsh, {David G.}",
note = "Funding Information: We thank the families in Barbados and the Amish families of Lancaster, Pennsylvania for their generous participation in this study; the physicians and staff of the Black Rock, Sir Winston Scott, Randal Phillips, Maurice Byer, Six Cross Roads, and St. John polyclinics and the Accident and Emergency Department, Queen Elizabeth Hospital; the staff of the Leptospira Laboratory, Barbados, for their technical support; and the Ministry of Health, Barbados, for permission to conduct this study. We are especially grateful to Maria Stockton and Kimberly Donnelly for assistance with the {\textregistered}eldwork in Barbados, to Wendy Warren for her {\textregistered}eldwork with the Amish under the direction of Dr. Wilma Bias, and for technical support with the Barbados data by Dana Mulkern, Suzen Moeller, and Xielun Xue. We greatly appreciate comments from Drs. Farhad Imani and Shau-Ku Huang. This work was funded by NIH Grant AI20059. K.C.B. was supported in part by a grant from the USDA±ARS; J.D.N. was also supported by a grant from the Lucille P. Markey Charitable Trust; and D.L.D. was the recipient of a Neil Hamilton Fairley Fellowship from the Australian National Health and Medical Research Council. The computer program package S.A.G.E. is supported by a U.S. Public Health Resource Grant (1 p41 RR03655) from the Division of Research Resources.",
year = "1996",
month = oct,
day = "1",
doi = "10.1006/geno.1996.0518",
language = "English (US)",
volume = "37",
pages = "41--50",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "1",
}