Linkage mapping of the AML1 gene on human chromosome 21 using a DNA polymorphism in the 3′ untranslated region

Dimitrios Avramopoulos, Tara Cox, Jillian E. Blaschak, Aravinda Chakravarti, Stylianos E. Antonarakis

Research output: Contribution to journalArticle

Abstract

We have detected a polymorphism in the 3′ untranslated region of the AML1 gene, which is located at the breakpoint on chromosome 21 in the t(8;21)(q22;q22.3) translocation often associated with patients with acute myeloid leukemia. Informative CEPH families were genotyped for this polymorphism and used to localize the gene on the linkage map of human chromosome 21. The AML1 gene is located between the markers D21S216 and D21S211, in chromosomal band 21q22.3.

Original languageEnglish (US)
Pages (from-to)506-507
Number of pages2
JournalGenomics
Volume14
Issue number2
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Genetics

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