TY - JOUR
T1 - Linkage mapping of the AML1 gene on human chromosome 21 using a DNA polymorphism in the 3′ untranslated region
AU - Avramopoulos, Dimitrios
AU - Cox, Tara
AU - Blaschak, Jillian E.
AU - Chakravarti, Aravinda
AU - Antonarakis, Stylianos E.
N1 - Funding Information:
This work was supported by NIH Grants HD24605 and HG00373 to S.E.A. and HD00774 (RCDA) and HG00344 to A.C.
PY - 1992/10
Y1 - 1992/10
N2 - We have detected a polymorphism in the 3′ untranslated region of the AML1 gene, which is located at the breakpoint on chromosome 21 in the t(8;21)(q22;q22.3) translocation often associated with patients with acute myeloid leukemia. Informative CEPH families were genotyped for this polymorphism and used to localize the gene on the linkage map of human chromosome 21. The AML1 gene is located between the markers D21S216 and D21S211, in chromosomal band 21q22.3.
AB - We have detected a polymorphism in the 3′ untranslated region of the AML1 gene, which is located at the breakpoint on chromosome 21 in the t(8;21)(q22;q22.3) translocation often associated with patients with acute myeloid leukemia. Informative CEPH families were genotyped for this polymorphism and used to localize the gene on the linkage map of human chromosome 21. The AML1 gene is located between the markers D21S216 and D21S211, in chromosomal band 21q22.3.
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U2 - 10.1016/S0888-7543(05)80253-8
DO - 10.1016/S0888-7543(05)80253-8
M3 - Article
C2 - 1427868
AN - SCOPUS:0026467158
SN - 0888-7543
VL - 14
SP - 506
EP - 507
JO - Genomics
JF - Genomics
IS - 2
ER -