Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21

Melvin G. McInnis; Georges Lutfalla; Susan Slaugenhaupt; Michael B. Petersen; Gilles Uze; Aravinda Chakravarti; Stylianos E. Antonarakis

doi:10.1016/0888-7543(91)90064-L

Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21

Melvin G. McInnis, Georges Lutfalla, Susan Slaugenhaupt, Michael B. Petersen, Gilles Uze, Aravinda Chakravarti, Stylianos E. Antonarakis

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT₃)_n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (θ̂ = 0.02, Z ̂ = 36.76) and D21S17 (θ̂ = 0.02, Z ̂ = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.

Original language	English (US)
Pages (from-to)	573-576
Number of pages	4
Journal	Genomics
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(91)90064-L
State	Published - Nov 1991

ASJC Scopus subject areas

Genetics

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Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21. / McInnis, Melvin G.; Lutfalla, Georges; Slaugenhaupt, Susan; Petersen, Michael B.; Uze, Gilles; Chakravarti, Aravinda; Antonarakis, Stylianos E.

In: Genomics, Vol. 11, No. 3, 11.1991, p. 573-576.

Research output: Contribution to journal › Article › peer-review

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title = "Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21",

abstract = "Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 ({\^θ} = 0.02, Z{\^ } = 36.76) and D21S17 ({\^θ} = 0.02, Z{\^ } = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.",

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AU - Petersen, Michael B.

AU - Uze, Gilles

AU - Chakravarti, Aravinda

AU - Antonarakis, Stylianos E.

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N2 - Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (θ̂ = 0.02, Z ̂ = 36.76) and D21S17 (θ̂ = 0.02, Z ̂ = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.

AB - Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (θ̂ = 0.02, Z ̂ = 36.76) and D21S17 (θ̂ = 0.02, Z ̂ = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.

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