TY - JOUR
T1 - Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21
AU - McInnis, Melvin G.
AU - Lutfalla, Georges
AU - Slaugenhaupt, Susan
AU - Petersen, Michael B.
AU - Uze, Gilles
AU - Chakravarti, Aravinda
AU - Antonarakis, Stylianos E.
N1 - Funding Information:
This research was supported by NIH Grants HD24605 (S.E.A.) and HGO0344 and HD 00774 (A.C.). M.G.M. was supported by a fellowship from NIA Grant AG00149, a research training grant in the dementias of aging. We thank Dr. Ion Greaser for support. G.L. and G.U. were supported by grants from DRET (89.34.132), AN-
PY - 1991/11
Y1 - 1991/11
N2 - Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (θ̂ = 0.02, Z ̂ = 36.76) and D21S17 (θ̂ = 0.02, Z ̂ = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.
AB - Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (θ̂ = 0.02, Z ̂ = 36.76) and D21S17 (θ̂ = 0.02, Z ̂ = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.
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U2 - 10.1016/0888-7543(91)90064-L
DO - 10.1016/0888-7543(91)90064-L
M3 - Article
C2 - 1685477
AN - SCOPUS:0026005342
VL - 11
SP - 573
EP - 576
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 3
ER -