Linkage disequilibrium in European Americans with bipolar disorder

Y. Chen, C. Yarnes, M. G. McInnis, F. J. McMahon

Research output: Contribution to journalArticle

Abstract

The success of SNP-based linkage disequilibrium (LD) mapping may depend on the extent of LD between adjacent markers, but little is known about the extent of inter-marker LD in non-isolated human populations. As a preliminary to SNP-based studies, we have physically mapped 13 chromosome 18q microsatellite markers on the TNG radiation hybrid panel at mean intervals of 237 kb. These markers were genotyped in a set of 58 European-American pedigrees collected for a linkage study of bipolar disorder. Genotypes were generated using semi-automated fluorescent methods and assembled into haplotypes. Haplotype data was analyzed for inter-marker LD in the unrelated probands using a Monte Carlo permutation of the Fisher Exact Test. Significant LD was observed for 5 out of the 11 adjacent marker pairs. There was also a significant relationship between the magnitude of LD and physical distance. Detectable LD was observed over a physical distance up to ∼ 400 kb. These results demonstrate that linkage disequilibrium can be detected over relatively large physical distances on chromosome 18q in European Americans with bipolar disorder.

Original languageEnglish (US)
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number4
StatePublished - Aug 7 2000

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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