TY - JOUR
T1 - Linkage analysis of the human HMG14 gene on chromosome 21 using a GT dinucleotide repeat as polymorphic marker
AU - Petersen, Michael B.
AU - Economou, Effrosini P.
AU - Slaugenhaupt, Susan A.
AU - Chakravarti, Aravinda
AU - Antonarakis, Stylianos E.
N1 - Funding Information:
a Fulbright Fellowship. E.P.E. was supported by Cooley’s Anemia Foundation of Maryland, and S.E.A. by NIH Grant ROl HD19591. A.C. was supported by NIH Grants GM33771 and Research Career Development Award HD00774. We thank Andrew C. Warren for comments on the manuscript.
Funding Information:
was supported by the Danish Research Council, Academy, Else og Mogens Wedell-Wedellsborgs
PY - 1990/5
Y1 - 1990/5
N2 - A (GT)n repeat in intron 4 of the functional human HMG14 gene on chromosome 21 was used as polymorphic marker to map this gene relative to the genetic linkage map of human chromosome 21. Variation in the length of the (GT)n repeat was detected by electrophoresis on polyacrylamide gels of DNA amplified by the polymerase chain reaction using primers flanking the repeat. The observed heterozygosity of this polymorphism in 40 CEPH families was 58% with six different alleles. Linkage analysis localized the HMG14 gene close to the ETS2 gene and locus D21S3 in chromosomal band 21q22.3.
AB - A (GT)n repeat in intron 4 of the functional human HMG14 gene on chromosome 21 was used as polymorphic marker to map this gene relative to the genetic linkage map of human chromosome 21. Variation in the length of the (GT)n repeat was detected by electrophoresis on polyacrylamide gels of DNA amplified by the polymerase chain reaction using primers flanking the repeat. The observed heterozygosity of this polymorphism in 40 CEPH families was 58% with six different alleles. Linkage analysis localized the HMG14 gene close to the ETS2 gene and locus D21S3 in chromosomal band 21q22.3.
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U2 - 10.1016/0888-7543(90)90531-X
DO - 10.1016/0888-7543(90)90531-X
M3 - Article
C2 - 1970797
AN - SCOPUS:0025425540
SN - 0888-7543
VL - 7
SP - 136
EP - 138
JO - Genomics
JF - Genomics
IS - 1
ER -