Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations

David G. Marsh, John D. Neely, Daniel R. Breazeale, Balaram Ghosh, Linda R. Freidhoff, Eva Ehrlich-Kautzky, Carsten Schou, Guha Krishnaswamy, Terri H. Beaty

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Abstract

Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.

Original languageEnglish (US)
Pages (from-to)1152-1156
Number of pages5
JournalScience
Volume264
Issue number5162
DOIs
StatePublished - May 20 1994

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    Marsh, D. G., Neely, J. D., Breazeale, D. R., Ghosh, B., Freidhoff, L. R., Ehrlich-Kautzky, E., Schou, C., Krishnaswamy, G., & Beaty, T. H. (1994). Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science, 264(5162), 1152-1156. https://doi.org/10.1126/science.8178175