Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23

Simeon A. Boyadjiev, Ethylin Wang Jabs, Michele LaBuda, Joseph E. Jamal, Torberg Torbergsen, Louis J. Ptáček, R. Curtis Rogers, Rolf Nyberg-Hansen, Stein Opjordsmoen, Cynthia B. Zeller, O. Colin Stine, Heather J. Stalker, Roberto T. Zori, Robert E. Shapiro

Research output: Contribution to journalArticle

Abstract

Oculodentodigital dysplasia (ODDD) is an autosomal dominant condition with high penetrance and variable expressivity. The anomalies of the craniofacial region, eyes, teeth, and limbs indicate abnormal morphogenesis during early fetal development. Neurologic abnormalities occur later in life and appear to be secondary to white matter degeneration and basal ganglia changes. In familial cases, the dysmorphic and/or neurodegenerative components of the phenotype can be more severe and/or present at a younger age in subsequent generations, suggesting genetic anticipation. These clinical features suggest that the ODDD gene is pleiotropic with important functions throughout pre- and postnatal development. We have performed two- point linkage analysis with seven ODDD families and 19 microsatellite markers on chromosome 6q spanning a genetic distance of approximately 11 cM in males and 20 cM in females. We have refined the location of the ODDD gene between DNA markers D6S266/D6S261 (centromeric) and D6S1639 (telomeric), an interval of 1.01 (male) to 2.87 (female) cM. The strongest linkage was to DNA marker D6S433 (Z(max) = 8.96, θ(max) = 0.001). Families show significant linkage to chromosome 6q22-q23 and no evidence for genetic heterogeneity.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalGenomics
Volume58
Issue number1
DOIs
StatePublished - May 15 1999

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Chromosomes
Genetic Markers
Genetic Anticipation
Genetic Pleiotropy
Nervous System Malformations
Genetic Heterogeneity
Penetrance
Phentolamine
Fetal Development
Basal Ganglia
Morphogenesis
Microsatellite Repeats
Tooth
Extremities
Phenotype
Oculodentodigital Dysplasia
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Boyadjiev, S. A., Jabs, E. W., LaBuda, M., Jamal, J. E., Torbergsen, T., Ptáček, L. J., ... Shapiro, R. E. (1999). Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23. Genomics, 58(1), 34-40. https://doi.org/10.1006/geno.1999.5814

Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23. / Boyadjiev, Simeon A.; Jabs, Ethylin Wang; LaBuda, Michele; Jamal, Joseph E.; Torbergsen, Torberg; Ptáček, Louis J.; Rogers, R. Curtis; Nyberg-Hansen, Rolf; Opjordsmoen, Stein; Zeller, Cynthia B.; Stine, O. Colin; Stalker, Heather J.; Zori, Roberto T.; Shapiro, Robert E.

In: Genomics, Vol. 58, No. 1, 15.05.1999, p. 34-40.

Research output: Contribution to journalArticle

Boyadjiev, SA, Jabs, EW, LaBuda, M, Jamal, JE, Torbergsen, T, Ptáček, LJ, Rogers, RC, Nyberg-Hansen, R, Opjordsmoen, S, Zeller, CB, Stine, OC, Stalker, HJ, Zori, RT & Shapiro, RE 1999, 'Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23', Genomics, vol. 58, no. 1, pp. 34-40. https://doi.org/10.1006/geno.1999.5814
Boyadjiev SA, Jabs EW, LaBuda M, Jamal JE, Torbergsen T, Ptáček LJ et al. Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23. Genomics. 1999 May 15;58(1):34-40. https://doi.org/10.1006/geno.1999.5814
Boyadjiev, Simeon A. ; Jabs, Ethylin Wang ; LaBuda, Michele ; Jamal, Joseph E. ; Torbergsen, Torberg ; Ptáček, Louis J. ; Rogers, R. Curtis ; Nyberg-Hansen, Rolf ; Opjordsmoen, Stein ; Zeller, Cynthia B. ; Stine, O. Colin ; Stalker, Heather J. ; Zori, Roberto T. ; Shapiro, Robert E. / Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23. In: Genomics. 1999 ; Vol. 58, No. 1. pp. 34-40.
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