Linkage analysis in lattice corneal dystrophy

J. D. Kivlin; E. W. Lovrien; I. H. Maumenee; D. T. Bishop; W. Bias

doi:10.1002/ajmg.1320190222

Linkage analysis in lattice corneal dystrophy

J. D. Kivlin, E. W. Lovrien, I. H. Maumenee, D. T. Bishop, W. Bias

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Two kindreds of lattice corneal dystrophy (LCD) [McKusick, 1983, catalog No. 12220] were studied for linkage. Fifty-one relatives were examined clinically, and 27 affected and 24 normal persons ascertained. Tight linkage could be excluded for 15 informative markers with LOD scores of less than -2.0. The largest positive LOD score was 0.56 at θ = 0.17 for linkage between haptoglobin and LCD. Combined with a previous study, the combined LOD score is 0.96.

Original language	English (US)
Pages (from-to)	387-390
Number of pages	4
Journal	American journal of medical genetics
Volume	19
Issue number	2
DOIs	https://doi.org/10.1002/ajmg.1320190222
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)

Access to Document

10.1002/ajmg.1320190222

Cite this

@article{60227ec3727e41f8b04d774e07083b67,

title = "Linkage analysis in lattice corneal dystrophy",

abstract = "Two kindreds of lattice corneal dystrophy (LCD) [McKusick, 1983, catalog No. 12220] were studied for linkage. Fifty-one relatives were examined clinically, and 27 affected and 24 normal persons ascertained. Tight linkage could be excluded for 15 informative markers with LOD scores of less than -2.0. The largest positive LOD score was 0.56 at θ = 0.17 for linkage between haptoglobin and LCD. Combined with a previous study, the combined LOD score is 0.96.",

author = "Kivlin, {J. D.} and Lovrien, {E. W.} and Maumenee, {I. H.} and Bishop, {D. T.} and W. Bias",

year = "1984",

doi = "10.1002/ajmg.1320190222",

language = "English (US)",

volume = "19",

pages = "387--390",

journal = "American Journal of Medical Genetics, Part A",

issn = "1552-4825",

publisher = "Wiley-Liss Inc.",

number = "2",

}

TY - JOUR

T1 - Linkage analysis in lattice corneal dystrophy

AU - Kivlin, J. D.

AU - Lovrien, E. W.

AU - Maumenee, I. H.

AU - Bishop, D. T.

AU - Bias, W.

PY - 1984

Y1 - 1984

N2 - Two kindreds of lattice corneal dystrophy (LCD) [McKusick, 1983, catalog No. 12220] were studied for linkage. Fifty-one relatives were examined clinically, and 27 affected and 24 normal persons ascertained. Tight linkage could be excluded for 15 informative markers with LOD scores of less than -2.0. The largest positive LOD score was 0.56 at θ = 0.17 for linkage between haptoglobin and LCD. Combined with a previous study, the combined LOD score is 0.96.

AB - Two kindreds of lattice corneal dystrophy (LCD) [McKusick, 1983, catalog No. 12220] were studied for linkage. Fifty-one relatives were examined clinically, and 27 affected and 24 normal persons ascertained. Tight linkage could be excluded for 15 informative markers with LOD scores of less than -2.0. The largest positive LOD score was 0.56 at θ = 0.17 for linkage between haptoglobin and LCD. Combined with a previous study, the combined LOD score is 0.96.

UR - http://www.scopus.com/inward/record.url?scp=0021739546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021739546&partnerID=8YFLogxK

U2 - 10.1002/ajmg.1320190222

DO - 10.1002/ajmg.1320190222

M3 - Article

C2 - 6334443

AN - SCOPUS:0021739546

VL - 19

SP - 387

EP - 390

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 1552-4825

IS - 2

ER -

Linkage analysis in lattice corneal dystrophy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this