Linkage analysis in lattice corneal dystrophy

J. D. Kivlin, E. W. Lovrien, I. H. Maumenee, D. T. Bishop, W. Bias

Research output: Contribution to journalArticlepeer-review

Abstract

Two kindreds of lattice corneal dystrophy (LCD) [McKusick, 1983, catalog No. 12220] were studied for linkage. Fifty-one relatives were examined clinically, and 27 affected and 24 normal persons ascertained. Tight linkage could be excluded for 15 informative markers with LOD scores of less than -2.0. The largest positive LOD score was 0.56 at θ = 0.17 for linkage between haptoglobin and LCD. Combined with a previous study, the combined LOD score is 0.96.

Original languageEnglish (US)
Pages (from-to)387-390
Number of pages4
JournalAmerican journal of medical genetics
Volume19
Issue number2
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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