Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis

Feng Sun, Qiaoling Ruan, Jiali Wang, Shu Chen, Jialin Jin, Lingyun Shao, Ying Zhang, Wenhong Zhang

Research output: Contribution to journalArticle

Abstract

We conducted a retrospective cohort study of patients with MRC grade II/III tuberculous meningitis (TBM) who accepted a background antitubercular regimen (BR) with or without linezolid (LZD). At the 4th week, the LZD-BR group achieved a faster and higher percentage of Glasgow coma scale recovery and temperature recovery, a higher cerebrospinal fluid (CSF)/blood glucose ratio, and lower CSF white blood cell counts than did the BR group. Short-term linezolid supplementation may be a more effective treatment for life-threatening TBM.Copyright

Original languageEnglish (US)
Pages (from-to)6297-6301
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number10
DOIs
StatePublished - Oct 1 2014

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Linezolid
Meningeal Tuberculosis
Therapeutic Uses
Cerebrospinal Fluid
Glasgow Coma Scale
Leukocyte Count
Blood Glucose
Cohort Studies
Retrospective Studies
Temperature

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis. / Sun, Feng; Ruan, Qiaoling; Wang, Jiali; Chen, Shu; Jin, Jialin; Shao, Lingyun; Zhang, Ying; Zhang, Wenhong.

In: Antimicrobial Agents and Chemotherapy, Vol. 58, No. 10, 01.10.2014, p. 6297-6301.

Research output: Contribution to journalArticle

Sun, Feng ; Ruan, Qiaoling ; Wang, Jiali ; Chen, Shu ; Jin, Jialin ; Shao, Lingyun ; Zhang, Ying ; Zhang, Wenhong. / Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis. In: Antimicrobial Agents and Chemotherapy. 2014 ; Vol. 58, No. 10. pp. 6297-6301.
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