Linezolid and lactic acidosis: A role for lactate monitoring with long-term linezolid use in children

Erik Su, Kelli Crowley, Joseph A. Carcillo, Marian G. Michaels

Research output: Contribution to journalArticlepeer-review

Abstract

Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.

Original languageEnglish (US)
Pages (from-to)804-806
Number of pages3
JournalPediatric Infectious Disease Journal
Volume30
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Pediatric
  • lactic acidosis
  • linezolid
  • mitochondria
  • multidrug resistance
  • vancomycin-resistant Enterococcus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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