Linezolid and lactic acidosis: A role for lactate monitoring with long-term linezolid use in children

Erik R Su, Kelli Crowley, Joseph A. Carcillo, Marian G. Michaels

Research output: Contribution to journalArticle

Abstract

Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.

Original languageEnglish (US)
Pages (from-to)804-806
Number of pages3
JournalPediatric Infectious Disease Journal
Volume30
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Linezolid
Lactic Acidosis
Lactic Acid
Mitochondrial Proteins
Caregivers
Pediatrics

Keywords

  • lactic acidosis
  • linezolid
  • mitochondria
  • multidrug resistance
  • Pediatric
  • vancomycin-resistant Enterococcus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Linezolid and lactic acidosis : A role for lactate monitoring with long-term linezolid use in children. / Su, Erik R; Crowley, Kelli; Carcillo, Joseph A.; Michaels, Marian G.

In: Pediatric Infectious Disease Journal, Vol. 30, No. 9, 09.2011, p. 804-806.

Research output: Contribution to journalArticle

Su, Erik R ; Crowley, Kelli ; Carcillo, Joseph A. ; Michaels, Marian G. / Linezolid and lactic acidosis : A role for lactate monitoring with long-term linezolid use in children. In: Pediatric Infectious Disease Journal. 2011 ; Vol. 30, No. 9. pp. 804-806.
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