Abstract
A new method of operation of the quadrupole ion‐trap mass spectrometer in the resonance ejection mode is introduced, that enables one to obtain accurate, linear mass calibration. The method employs linear modulation of the excitation voltage applied to the end‐caps while scanning the RF trapping field on the ring electrode. Calibration lines can be defined by a single calibration point because they converge near the reference point where the mass and trapping voltage are equal to zero. Mass assignment accuracy is achieved which is within, or of the order of, errors usually associated with the space‐charge effect. The method was implemented on a modified ion‐trap detector for ions formed by matrix‐assisted laser desorption, but can be used with other ionization techniques and applied to both external and internal calibration routines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 766-776 |
| Number of pages | 11 |
| Journal | Rapid Communications in Mass Spectrometry |
| Volume | 8 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1994 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Spectroscopy
- Organic Chemistry
Cite this
Linear mass calibration in the quadrupole ion‐trap mass spectrometer. / Doroshenko, Vladimir M.; Cotter, Robert J.; Lubman, D. M.
In: Rapid Communications in Mass Spectrometry, Vol. 8, No. 9, 1994, p. 766-776.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Linear mass calibration in the quadrupole ion‐trap mass spectrometer
AU - Doroshenko, Vladimir M.
AU - Cotter, Robert J.
AU - Lubman, D. M.
PY - 1994
Y1 - 1994
N2 - A new method of operation of the quadrupole ion‐trap mass spectrometer in the resonance ejection mode is introduced, that enables one to obtain accurate, linear mass calibration. The method employs linear modulation of the excitation voltage applied to the end‐caps while scanning the RF trapping field on the ring electrode. Calibration lines can be defined by a single calibration point because they converge near the reference point where the mass and trapping voltage are equal to zero. Mass assignment accuracy is achieved which is within, or of the order of, errors usually associated with the space‐charge effect. The method was implemented on a modified ion‐trap detector for ions formed by matrix‐assisted laser desorption, but can be used with other ionization techniques and applied to both external and internal calibration routines.
AB - A new method of operation of the quadrupole ion‐trap mass spectrometer in the resonance ejection mode is introduced, that enables one to obtain accurate, linear mass calibration. The method employs linear modulation of the excitation voltage applied to the end‐caps while scanning the RF trapping field on the ring electrode. Calibration lines can be defined by a single calibration point because they converge near the reference point where the mass and trapping voltage are equal to zero. Mass assignment accuracy is achieved which is within, or of the order of, errors usually associated with the space‐charge effect. The method was implemented on a modified ion‐trap detector for ions formed by matrix‐assisted laser desorption, but can be used with other ionization techniques and applied to both external and internal calibration routines.
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UR - http://www.scopus.com/inward/citedby.url?scp=84990712124&partnerID=8YFLogxK
U2 - 10.1002/rcm.1290080922
DO - 10.1002/rcm.1290080922
M3 - Article
AN - SCOPUS:84990712124
VL - 8
SP - 766
EP - 776
JO - Rapid Communications in Mass Spectrometry
JF - Rapid Communications in Mass Spectrometry
SN - 0951-4198
IS - 9
ER -