Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case Report

Victoria S. Humphrey, Jonathan J. Lee, Teerawit Supakorndej, Shahid M. Malik, Arthur C. Huen, Jedrych Jaroslaw

Research output: Contribution to journalArticle

Abstract

Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. This exceptional case further validates the association between LABD with UC, strengthens that with PSC, and underscores the importance of alerting clinicians to consider conducting a systemic workup in addition to thorough medication history on making the diagnosis of LABD.

Original languageEnglish (US)
Pages (from-to)498-501
Number of pages4
JournalAmerican Journal of Dermatopathology
Volume41
Issue number7
DOIs
StatePublished - Jul 1 2019
Externally publishedYes

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Keywords

  • linear IgA bullous dermatosis
  • primary sclerosing cholangitis
  • ulcerative colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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