TY - JOUR
T1 - Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis
T2 - A Case Report
AU - Humphrey, Victoria S.
AU - Lee, Jonathan J.
AU - Supakorndej, Teerawit
AU - Malik, Shahid M.
AU - Huen, Arthur C.
AU - Jaroslaw, Jedrych
N1 - Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. This exceptional case further validates the association between LABD with UC, strengthens that with PSC, and underscores the importance of alerting clinicians to consider conducting a systemic workup in addition to thorough medication history on making the diagnosis of LABD.
AB - Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. This exceptional case further validates the association between LABD with UC, strengthens that with PSC, and underscores the importance of alerting clinicians to consider conducting a systemic workup in addition to thorough medication history on making the diagnosis of LABD.
KW - linear IgA bullous dermatosis
KW - primary sclerosing cholangitis
KW - ulcerative colitis
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U2 - 10.1097/DAD.0000000000001313
DO - 10.1097/DAD.0000000000001313
M3 - Article
C2 - 30461424
AN - SCOPUS:85068576274
SN - 0193-1091
VL - 41
SP - 498
EP - 501
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 7
ER -