Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI

Wonsang You, Feng Xu, Catherine Limperopoulos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional MRI studies have started the hemodynamic responses of the placenta and fetal brain using maternal hyperoxia. While most studies have focused on analyzing the changes in magnitude of fMRI signals, few studies have analyzed the latency and duration of responses to hyperoxia. This paper proposes a linear convolution model of fetal circulation where a chain of responses to maternal hyperoxia are produced in the placenta and fetal brain. Specifically, an impulse response to hyperoxia was modeled as the hemodynamic response function (HRF) which consists of multiple gamma functions. Both time-to-peak and full width at half maximum of HRF were estimated using simulated annealing (SA). A Monte Carlo simulation was carried out to evaluate the performance of the SA-based method for estimating both parameters. Finally, we provided an example of estimating HRFs from fMRI time series of the placenta and fetal brain acquired during maternal hyperoxia in vivo.

Original languageEnglish (US)
Title of host publication2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PublisherIEEE Computer Society
Pages1284-1287
Number of pages4
ISBN (Electronic)9781538636367
DOIs
StatePublished - May 23 2018
Externally publishedYes
Event15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 - Washington, United States
Duration: Apr 4 2018Apr 7 2018

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2018-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
CountryUnited States
CityWashington
Period4/4/184/7/18

Fingerprint

Hyperoxia
Hemodynamics
Convolution
Linear Models
Brain
Mothers
Magnetic Resonance Imaging
Simulated annealing
Placenta
Full width at half maximum
Impulse response
Time series
Reaction Time

Keywords

  • Fetal brain
  • FMRI
  • Hemodynamic response function
  • Hyperoxia
  • Linear convolution model
  • Placenta

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

You, W., Xu, F., & Limperopoulos, C. (2018). Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI. In 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018 (pp. 1284-1287). (Proceedings - International Symposium on Biomedical Imaging; Vol. 2018-April). IEEE Computer Society. https://doi.org/10.1109/ISBI.2018.8363806

Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI. / You, Wonsang; Xu, Feng; Limperopoulos, Catherine.

2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. IEEE Computer Society, 2018. p. 1284-1287 (Proceedings - International Symposium on Biomedical Imaging; Vol. 2018-April).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

You, W, Xu, F & Limperopoulos, C 2018, Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI. in 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. Proceedings - International Symposium on Biomedical Imaging, vol. 2018-April, IEEE Computer Society, pp. 1284-1287, 15th IEEE International Symposium on Biomedical Imaging, ISBI 2018, Washington, United States, 4/4/18. https://doi.org/10.1109/ISBI.2018.8363806
You W, Xu F, Limperopoulos C. Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI. In 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. IEEE Computer Society. 2018. p. 1284-1287. (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2018.8363806
You, Wonsang ; Xu, Feng ; Limperopoulos, Catherine. / Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI. 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. IEEE Computer Society, 2018. pp. 1284-1287 (Proceedings - International Symposium on Biomedical Imaging).
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