Abstract
Analysis of the critical cellular processes of self-generation, commitment, and maturation induction ideally requires the use of clonal cultures using cells with a capacity to undergo allthree processes. Preprogenitor cells from normal mouse marrow are proving useful cells for such studies. Cells of a newly established cloned leukemic cell line, the GB2, are providing a useful analogous leukemic system because GB2 cells form stratified subpopulations of clonogenic cells able to be clonally analyzed in vitro in which self-renewal is demonstrable, but in which near-normal maturation can be induced by a wide range of hematopoietic regulators.
Original language | English (US) |
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Pages (from-to) | 278-292 |
Number of pages | 15 |
Journal | Annals of the New York Academy of Sciences |
Volume | 938 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Blast colonies
- Commitment
- Cytokines
- Hematopoiesis
- Leukemia
- Maturation
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science