Abstract
Analysis of the critical cellular processes of self-generation, commitment, and maturation induction ideally requires the use of clonal cultures using cells with a capacity to undergo allthree processes. Preprogenitor cells from normal mouse marrow are proving useful cells for such studies. Cells of a newly established cloned leukemic cell line, the GB2, are providing a useful analogous leukemic system because GB2 cells form stratified subpopulations of clonogenic cells able to be clonally analyzed in vitro in which self-renewal is demonstrable, but in which near-normal maturation can be induced by a wide range of hematopoietic regulators.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 278-292 |
| Number of pages | 15 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 938 |
| DOIs | |
| State | Published - 2001 |
Keywords
- Blast colonies
- Commitment
- Cytokines
- Hematopoiesis
- Leukemia
- Maturation
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
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Cite this
Metcalf, D., Laâbi, Y., Moore, M., Lansdorp, P., Sharkis, S., Keller, G., Löwenberg, B., & Dick, J. E. (2001). Lineage commitment and maturation induction in normal and leukemic preprogenitor cells. Annals of the New York Academy of Sciences, 938, 278-292. https://doi.org/10.1111/j.1749-6632.2001.tb03597.x