Lineage Commitment and Cellular Differentiation in Exocrine Pancreas

Anna L. Means, Steven D. Leach

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Exocrine pancreatic cell types comprise greater than 90% of parenchymal cell mass in the adult pancreas. However, the factors regulating differentiation of acinar and ductal epithelial cells remain incompletely characterized. Like pancreatic islet cells, acinar and ductal cells arise from pluripotent precursors within embryonic pancreatic epithelium. Recent studies have suggested that a common pool of pluripotent stem cells is responsible for generating both endocrine and exocrine cell types, and that specific signaling pathways regulate a critical balance between endocrine and exocrine lineage commitment.

Original languageEnglish (US)
Pages (from-to)587-596
Number of pages10
Issue number6
StatePublished - 2001
Externally publishedYes


  • Acinar cells
  • Notch
  • Pancreatic duct
  • Stem cells
  • Transcription factors
  • Transdifferentiation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology


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