LINE drive: Retrotransposition and genome instability

Research output: Contribution to journalReview articlepeer-review

Abstract

The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalCell
Volume110
Issue number3
DOIs
StatePublished - Aug 9 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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