LINE-1 retrotransposons

Modulators of quantity and quality of mammalian gene expression?

Jeffrey S. Han, Jef D. Boeke

Research output: Contribution to journalArticle

Abstract

LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA-binding protein, and ORF2, an endonuclease/ reverse transcriptase. Both proteins are required for L1 mobilization. Apart from the obvious function of self-replication, it is not clear what other roles, if any, L1 plays within its host. The sheer magnitude of L1 sequences in our genome has fueled speculation that over evolutionary time L1 insertions may structurally modify endogenous genes and regulate gene expression. Here we provide a review of L1 replication and its potential functional consequences.

Original languageEnglish (US)
Pages (from-to)775-784
Number of pages10
JournalBioEssays
Volume27
Issue number8
DOIs
StatePublished - Aug 2005

Fingerprint

Retroelements
retrotransposons
Gene expression
Modulators
Genes
Genome
Gene Expression
gene expression
RNA-Binding Proteins
genome
Endonucleases
RNA-Directed DNA Polymerase
Human Genome
RNA-binding proteins
Proteins
RNA-directed DNA polymerase
proteins
genes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

LINE-1 retrotransposons : Modulators of quantity and quality of mammalian gene expression? / Han, Jeffrey S.; Boeke, Jef D.

In: BioEssays, Vol. 27, No. 8, 08.2005, p. 775-784.

Research output: Contribution to journalArticle

Han, Jeffrey S. ; Boeke, Jef D. / LINE-1 retrotransposons : Modulators of quantity and quality of mammalian gene expression?. In: BioEssays. 2005 ; Vol. 27, No. 8. pp. 775-784.
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