LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer

Jennifer Permuth-Wey, Donghwa Kim, Ya Yu Tsai, Hui Yi Lin, Y. Ann Chen, Jill Barnholtz-Sloan, Michael J. Birrer, Gregory Bloom, Stephen J. Chanock, Zhihua Chen, Daniel W. Cramer, Julie M. Cunningham, Getachew Dagne, Judith Ebbert-Syfrett, David Fenstermacher, Brooke L. Fridley, Montserrat Garcia-Closas, Simon A. Gayther, William Ge, Aleksandra Gentry-MaharajJesus Gonzalez-Bosquet, Ellen L. Goode, Edwin Iversen, Heather Jim, William Kong, John McLaughlin, Usha Menon, Alvaro N A Monteiro, Steven A. Narod, Paul D P Pharoah, Catherine M. Phelan, Xiaotao Qu, Susan J. Ramus, Harvey Risch, Joellen M. Schildkraut, Honglin Song, Heather Stockwell, Rebecca Sutphen, Kathryn L. Terry, Jonathan Tyrer, Robert A. Vierkant, Nicolas Wentzensen, Johnathan M. Lancaster, Jin Q. Cheng, Thomas A. Sellers

Research output: Contribution to journalArticle

Abstract

Defective microRNA (miRNA) biogenesis contributes to the development and progression of epithelial ovarian cancer (EOC). In this study, we examined the hypothesis that single nucleotide polymorphisms (SNP) in miRNA biogenesis genes may influence EOC risk. In an initial investigation, 318 SNPs in 18 genes were evaluated among 1,815 EOC cases and 1,900 controls, followed up by a replicative joint meta-analysis of data from an additional 2,172 cases and 3,052 controls. Of 23 SNPs from 9 genes associated with risk (empirical P <0.05) in the initial investigation, the meta-analysis replicated 6 SNPs from the DROSHA, FMR1, LIN28, and LIN28B genes, including rs12194974 (G>A), an SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR = 0.90, 95% CI: 0.82-0.98; P = 0.015) which has been recently implicated in age of menarche and other phenotypes. Consistent with reports that LIN28B overexpression in EOC contributes to tumorigenesis by repressing tumor suppressor let-7 expression, we provide data from luciferase reporter assays and quantitative RT-PCR to suggest that the inverse association among rs12194974 A allele carriers may be because of reduced LIN28B expression. Our findings suggest that variants in LIN28B and possibly other miRNA biogenesis genes may influence EOC susceptibility.

Original languageEnglish (US)
Pages (from-to)3896-3903
Number of pages8
JournalCancer Research
Volume71
Issue number11
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

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Single Nucleotide Polymorphism
MicroRNAs
Genes
Menarche
Luciferases
Genetic Promoter Regions
Meta-Analysis
Carcinogenesis
Transcription Factors
Joints
Alleles
Binding Sites
Ovarian epithelial cancer
Phenotype
Polymerase Chain Reaction
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Permuth-Wey, J., Kim, D., Tsai, Y. Y., Lin, H. Y., Chen, Y. A., Barnholtz-Sloan, J., ... Sellers, T. A. (2011). LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. Cancer Research, 71(11), 3896-3903. https://doi.org/10.1158/0008-5472.CAN-10-4167

LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. / Permuth-Wey, Jennifer; Kim, Donghwa; Tsai, Ya Yu; Lin, Hui Yi; Chen, Y. Ann; Barnholtz-Sloan, Jill; Birrer, Michael J.; Bloom, Gregory; Chanock, Stephen J.; Chen, Zhihua; Cramer, Daniel W.; Cunningham, Julie M.; Dagne, Getachew; Ebbert-Syfrett, Judith; Fenstermacher, David; Fridley, Brooke L.; Garcia-Closas, Montserrat; Gayther, Simon A.; Ge, William; Gentry-Maharaj, Aleksandra; Gonzalez-Bosquet, Jesus; Goode, Ellen L.; Iversen, Edwin; Jim, Heather; Kong, William; McLaughlin, John; Menon, Usha; Monteiro, Alvaro N A; Narod, Steven A.; Pharoah, Paul D P; Phelan, Catherine M.; Qu, Xiaotao; Ramus, Susan J.; Risch, Harvey; Schildkraut, Joellen M.; Song, Honglin; Stockwell, Heather; Sutphen, Rebecca; Terry, Kathryn L.; Tyrer, Jonathan; Vierkant, Robert A.; Wentzensen, Nicolas; Lancaster, Johnathan M.; Cheng, Jin Q.; Sellers, Thomas A.

In: Cancer Research, Vol. 71, No. 11, 01.06.2011, p. 3896-3903.

Research output: Contribution to journalArticle

Permuth-Wey, J, Kim, D, Tsai, YY, Lin, HY, Chen, YA, Barnholtz-Sloan, J, Birrer, MJ, Bloom, G, Chanock, SJ, Chen, Z, Cramer, DW, Cunningham, JM, Dagne, G, Ebbert-Syfrett, J, Fenstermacher, D, Fridley, BL, Garcia-Closas, M, Gayther, SA, Ge, W, Gentry-Maharaj, A, Gonzalez-Bosquet, J, Goode, EL, Iversen, E, Jim, H, Kong, W, McLaughlin, J, Menon, U, Monteiro, ANA, Narod, SA, Pharoah, PDP, Phelan, CM, Qu, X, Ramus, SJ, Risch, H, Schildkraut, JM, Song, H, Stockwell, H, Sutphen, R, Terry, KL, Tyrer, J, Vierkant, RA, Wentzensen, N, Lancaster, JM, Cheng, JQ & Sellers, TA 2011, 'LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer', Cancer Research, vol. 71, no. 11, pp. 3896-3903. https://doi.org/10.1158/0008-5472.CAN-10-4167
Permuth-Wey J, Kim D, Tsai YY, Lin HY, Chen YA, Barnholtz-Sloan J et al. LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. Cancer Research. 2011 Jun 1;71(11):3896-3903. https://doi.org/10.1158/0008-5472.CAN-10-4167
Permuth-Wey, Jennifer ; Kim, Donghwa ; Tsai, Ya Yu ; Lin, Hui Yi ; Chen, Y. Ann ; Barnholtz-Sloan, Jill ; Birrer, Michael J. ; Bloom, Gregory ; Chanock, Stephen J. ; Chen, Zhihua ; Cramer, Daniel W. ; Cunningham, Julie M. ; Dagne, Getachew ; Ebbert-Syfrett, Judith ; Fenstermacher, David ; Fridley, Brooke L. ; Garcia-Closas, Montserrat ; Gayther, Simon A. ; Ge, William ; Gentry-Maharaj, Aleksandra ; Gonzalez-Bosquet, Jesus ; Goode, Ellen L. ; Iversen, Edwin ; Jim, Heather ; Kong, William ; McLaughlin, John ; Menon, Usha ; Monteiro, Alvaro N A ; Narod, Steven A. ; Pharoah, Paul D P ; Phelan, Catherine M. ; Qu, Xiaotao ; Ramus, Susan J. ; Risch, Harvey ; Schildkraut, Joellen M. ; Song, Honglin ; Stockwell, Heather ; Sutphen, Rebecca ; Terry, Kathryn L. ; Tyrer, Jonathan ; Vierkant, Robert A. ; Wentzensen, Nicolas ; Lancaster, Johnathan M. ; Cheng, Jin Q. ; Sellers, Thomas A. / LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. In: Cancer Research. 2011 ; Vol. 71, No. 11. pp. 3896-3903.
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abstract = "Defective microRNA (miRNA) biogenesis contributes to the development and progression of epithelial ovarian cancer (EOC). In this study, we examined the hypothesis that single nucleotide polymorphisms (SNP) in miRNA biogenesis genes may influence EOC risk. In an initial investigation, 318 SNPs in 18 genes were evaluated among 1,815 EOC cases and 1,900 controls, followed up by a replicative joint meta-analysis of data from an additional 2,172 cases and 3,052 controls. Of 23 SNPs from 9 genes associated with risk (empirical P <0.05) in the initial investigation, the meta-analysis replicated 6 SNPs from the DROSHA, FMR1, LIN28, and LIN28B genes, including rs12194974 (G>A), an SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR = 0.90, 95{\%} CI: 0.82-0.98; P = 0.015) which has been recently implicated in age of menarche and other phenotypes. Consistent with reports that LIN28B overexpression in EOC contributes to tumorigenesis by repressing tumor suppressor let-7 expression, we provide data from luciferase reporter assays and quantitative RT-PCR to suggest that the inverse association among rs12194974 A allele carriers may be because of reduced LIN28B expression. Our findings suggest that variants in LIN28B and possibly other miRNA biogenesis genes may influence EOC susceptibility.",
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AU - Barnholtz-Sloan, Jill

AU - Birrer, Michael J.

AU - Bloom, Gregory

AU - Chanock, Stephen J.

AU - Chen, Zhihua

AU - Cramer, Daniel W.

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AU - Ge, William

AU - Gentry-Maharaj, Aleksandra

AU - Gonzalez-Bosquet, Jesus

AU - Goode, Ellen L.

AU - Iversen, Edwin

AU - Jim, Heather

AU - Kong, William

AU - McLaughlin, John

AU - Menon, Usha

AU - Monteiro, Alvaro N A

AU - Narod, Steven A.

AU - Pharoah, Paul D P

AU - Phelan, Catherine M.

AU - Qu, Xiaotao

AU - Ramus, Susan J.

AU - Risch, Harvey

AU - Schildkraut, Joellen M.

AU - Song, Honglin

AU - Stockwell, Heather

AU - Sutphen, Rebecca

AU - Terry, Kathryn L.

AU - Tyrer, Jonathan

AU - Vierkant, Robert A.

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AU - Cheng, Jin Q.

AU - Sellers, Thomas A.

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