Limited dermal ossification: Clinical features and natural history

Carol M. Foster, Sondra Levin, Michael Levine, Anil Mukherjee, Jonathan L. Costa, Edward D. Eanes, Timothy Triche, Michael Zasloff

Research output: Contribution to journalArticle

Abstract

For 9 years we have observed a girl who has ossification in the dermis with astrikingly limited distribution. Recently a second girl with similar dermal ossification restricted to a single extremity was identified. The ectopic bone is histologically identical to normal membranous bone. These two patients have no obvious underlying cause for soft tissue bone formation, and no disorder of calcium or phosphate metabolism. Ossification first involved the dermal and subcutaneous connective tissue, and with time advanced locally in the affected areas to bridge joints and limit mobility. The ossification has now extended to involve muscle fascia but has not involved the muscle itself. This disease appears to represent a heretofore unrecognized disorder of mesenchymal differentiation.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalJournal of Pediatrics
Volume109
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Natural History
Osteogenesis
Skin
Bone and Bones
Muscles
Fascia
Subcutaneous Tissue
Dermis
Connective Tissue
Extremities
Joints

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Foster, C. M., Levin, S., Levine, M., Mukherjee, A., Costa, J. L., Eanes, E. D., ... Zasloff, M. (1986). Limited dermal ossification: Clinical features and natural history. Journal of Pediatrics, 109(1), 71-76. https://doi.org/10.1016/S0022-3476(86)80575-3

Limited dermal ossification : Clinical features and natural history. / Foster, Carol M.; Levin, Sondra; Levine, Michael; Mukherjee, Anil; Costa, Jonathan L.; Eanes, Edward D.; Triche, Timothy; Zasloff, Michael.

In: Journal of Pediatrics, Vol. 109, No. 1, 1986, p. 71-76.

Research output: Contribution to journalArticle

Foster, CM, Levin, S, Levine, M, Mukherjee, A, Costa, JL, Eanes, ED, Triche, T & Zasloff, M 1986, 'Limited dermal ossification: Clinical features and natural history', Journal of Pediatrics, vol. 109, no. 1, pp. 71-76. https://doi.org/10.1016/S0022-3476(86)80575-3
Foster CM, Levin S, Levine M, Mukherjee A, Costa JL, Eanes ED et al. Limited dermal ossification: Clinical features and natural history. Journal of Pediatrics. 1986;109(1):71-76. https://doi.org/10.1016/S0022-3476(86)80575-3
Foster, Carol M. ; Levin, Sondra ; Levine, Michael ; Mukherjee, Anil ; Costa, Jonathan L. ; Eanes, Edward D. ; Triche, Timothy ; Zasloff, Michael. / Limited dermal ossification : Clinical features and natural history. In: Journal of Pediatrics. 1986 ; Vol. 109, No. 1. pp. 71-76.
@article{c7cbf4e42dce40b98a152ee2f11ff1f1,
title = "Limited dermal ossification: Clinical features and natural history",
abstract = "For 9 years we have observed a girl who has ossification in the dermis with astrikingly limited distribution. Recently a second girl with similar dermal ossification restricted to a single extremity was identified. The ectopic bone is histologically identical to normal membranous bone. These two patients have no obvious underlying cause for soft tissue bone formation, and no disorder of calcium or phosphate metabolism. Ossification first involved the dermal and subcutaneous connective tissue, and with time advanced locally in the affected areas to bridge joints and limit mobility. The ossification has now extended to involve muscle fascia but has not involved the muscle itself. This disease appears to represent a heretofore unrecognized disorder of mesenchymal differentiation.",
author = "Foster, {Carol M.} and Sondra Levin and Michael Levine and Anil Mukherjee and Costa, {Jonathan L.} and Eanes, {Edward D.} and Timothy Triche and Michael Zasloff",
year = "1986",
doi = "10.1016/S0022-3476(86)80575-3",
language = "English (US)",
volume = "109",
pages = "71--76",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Limited dermal ossification

T2 - Clinical features and natural history

AU - Foster, Carol M.

AU - Levin, Sondra

AU - Levine, Michael

AU - Mukherjee, Anil

AU - Costa, Jonathan L.

AU - Eanes, Edward D.

AU - Triche, Timothy

AU - Zasloff, Michael

PY - 1986

Y1 - 1986

N2 - For 9 years we have observed a girl who has ossification in the dermis with astrikingly limited distribution. Recently a second girl with similar dermal ossification restricted to a single extremity was identified. The ectopic bone is histologically identical to normal membranous bone. These two patients have no obvious underlying cause for soft tissue bone formation, and no disorder of calcium or phosphate metabolism. Ossification first involved the dermal and subcutaneous connective tissue, and with time advanced locally in the affected areas to bridge joints and limit mobility. The ossification has now extended to involve muscle fascia but has not involved the muscle itself. This disease appears to represent a heretofore unrecognized disorder of mesenchymal differentiation.

AB - For 9 years we have observed a girl who has ossification in the dermis with astrikingly limited distribution. Recently a second girl with similar dermal ossification restricted to a single extremity was identified. The ectopic bone is histologically identical to normal membranous bone. These two patients have no obvious underlying cause for soft tissue bone formation, and no disorder of calcium or phosphate metabolism. Ossification first involved the dermal and subcutaneous connective tissue, and with time advanced locally in the affected areas to bridge joints and limit mobility. The ossification has now extended to involve muscle fascia but has not involved the muscle itself. This disease appears to represent a heretofore unrecognized disorder of mesenchymal differentiation.

UR - http://www.scopus.com/inward/record.url?scp=0022568761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022568761&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(86)80575-3

DO - 10.1016/S0022-3476(86)80575-3

M3 - Article

C2 - 3088245

AN - SCOPUS:0022568761

VL - 109

SP - 71

EP - 76

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 1

ER -