Limitations of the cyanide electrode for use in plasma and whole blood

J. R. Kistner; D. E. Longnecker; E. D. Miller; A. D. Lescanic

doi:10.1213/00000539-197911000-00003

Limitations of the cyanide electrode for use in plasma and whole blood

J. R. Kistner, D. E. Longnecker, E. D. Miller, A. D. Lescanic

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8 Scopus citations

Abstract

Although the cyanide ion-specific electrode has been used for the measurement of cyanide in biologic fluids, its validity has not been documented under these conditions. Therefore, we analyzed 60 paired samples of blood and plasma in a blinded fashion and compared the cyanide ion concentrations obtained from the ion-specific electrode with those obtained from a standard chemical assay. There was poor correlation between results in plasma samples (r = .52, n = 26) and no correlation in whole blood (r = .02, n = 34). Until refinements of the electrode technique are made, this method cannot be recommended for the measurement of cyanide in biologic fluids.

Original language	English (US)
Pages (from-to)	457-460
Number of pages	4
Journal	Anesthesia and analgesia
Volume	58
Issue number	6
DOIs	https://doi.org/10.1213/00000539-197911000-00003
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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abstract = "Although the cyanide ion-specific electrode has been used for the measurement of cyanide in biologic fluids, its validity has not been documented under these conditions. Therefore, we analyzed 60 paired samples of blood and plasma in a blinded fashion and compared the cyanide ion concentrations obtained from the ion-specific electrode with those obtained from a standard chemical assay. There was poor correlation between results in plasma samples (r = .52, n = 26) and no correlation in whole blood (r = .02, n = 34). Until refinements of the electrode technique are made, this method cannot be recommended for the measurement of cyanide in biologic fluids.",

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AU - Kistner, J. R.

AU - Longnecker, D. E.

AU - Miller, E. D.

AU - Lescanic, A. D.

PY - 1979

Y1 - 1979

N2 - Although the cyanide ion-specific electrode has been used for the measurement of cyanide in biologic fluids, its validity has not been documented under these conditions. Therefore, we analyzed 60 paired samples of blood and plasma in a blinded fashion and compared the cyanide ion concentrations obtained from the ion-specific electrode with those obtained from a standard chemical assay. There was poor correlation between results in plasma samples (r = .52, n = 26) and no correlation in whole blood (r = .02, n = 34). Until refinements of the electrode technique are made, this method cannot be recommended for the measurement of cyanide in biologic fluids.

AB - Although the cyanide ion-specific electrode has been used for the measurement of cyanide in biologic fluids, its validity has not been documented under these conditions. Therefore, we analyzed 60 paired samples of blood and plasma in a blinded fashion and compared the cyanide ion concentrations obtained from the ion-specific electrode with those obtained from a standard chemical assay. There was poor correlation between results in plasma samples (r = .52, n = 26) and no correlation in whole blood (r = .02, n = 34). Until refinements of the electrode technique are made, this method cannot be recommended for the measurement of cyanide in biologic fluids.

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Limitations of the cyanide electrode for use in plasma and whole blood

Abstract

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