Limitations of power-spectrum and time-domain analysis of heart rate variability in short-term ECG recorded using telemetry in unrestrained rats

Jean Philippe Couderc, A. Elder, C. Cox, W. Zareba, G. Oberdorster

Research output: Contribution to journalConference article

Abstract

Radio-telemetry technique used to record electro - physiological signals in animals is broadly used in experimental studies. Using implantable probes, this technique can record electrocardiographic (ECG) signals without disturbing animal activities. In this study, we investigated the stability of heart rate variability (HRV) parameters computed from radio-telemetry ECG recordings in unrestrained rats. The experiment involved 4 normal rats in which ECGs were recorded during baseline conditions with and without drug-induced autonomie blockade. The study revealed that the stability of HRV estimators for both time and frequency domains analysis in unrestrained rats was highly dependent on the average heart rate (related to physical rats activity) as well as the length of the ECG recording.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalComputers in cardiology
Volume29
StatePublished - Dec 1 2002
Externally publishedYes
EventComputers in Cardiology 2002 - Memphis, TN, United States
Duration: Sep 22 2002Sep 25 2002

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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