LIGHT-related molecular network in the regulation of innate and adaptive immunity

Yanhui Xu; Koji Tamada; Lieping Chen

doi:10.1007/BF02686093

LIGHT-related molecular network in the regulation of innate and adaptive immunity

Yanhui Xu, Koji Tamada, Lieping Chen

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.

Original language	English (US)
Pages (from-to)	17-31
Number of pages	15
Journal	Immunologic Research
Volume	37
Issue number	1
DOIs	https://doi.org/10.1007/BF02686093
State	Published - Jan 2007

Keywords

BTLA
HVEM
LIGHT
LTβR
T cell activation
T cell-mediated diseases

ASJC Scopus subject areas

Immunology

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10.1007/BF02686093

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abstract = "The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.",

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AB - The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.

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KW - LTβR

KW - T cell activation

KW - T cell-mediated diseases

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LIGHT-related molecular network in the regulation of innate and adaptive immunity

Abstract

Keywords

ASJC Scopus subject areas

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