LIGHT-related molecular network in the regulation of innate and adaptive immunity

Yanhui Xu, Koji Tamada, Lieping Chen

Research output: Contribution to journalArticlepeer-review

Abstract

The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.

Original languageEnglish (US)
Pages (from-to)17-31
Number of pages15
JournalImmunologic Research
Volume37
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • BTLA
  • HVEM
  • LIGHT
  • LTβR
  • T cell activation
  • T cell-mediated diseases

ASJC Scopus subject areas

  • Immunology

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