LIGHT-related molecular network in the regulation of innate and adaptive immunity

Yanhui Xu, Koji Tamada, Lieping Chen

Research output: Contribution to journalArticle

Abstract

The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.

Original languageEnglish (US)
Pages (from-to)17-31
Number of pages15
JournalImmunologic Research
Volume37
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Adaptive Immunity
Innate Immunity
Transplantation Tolerance
Light
Autoimmune Diseases
Ligands
Infection
Neoplasms
Therapeutics

Keywords

  • BTLA
  • HVEM
  • LIGHT
  • LTβR
  • T cell activation
  • T cell-mediated diseases

ASJC Scopus subject areas

  • Immunology

Cite this

LIGHT-related molecular network in the regulation of innate and adaptive immunity. / Xu, Yanhui; Tamada, Koji; Chen, Lieping.

In: Immunologic Research, Vol. 37, No. 1, 01.2007, p. 17-31.

Research output: Contribution to journalArticle

Xu, Yanhui ; Tamada, Koji ; Chen, Lieping. / LIGHT-related molecular network in the regulation of innate and adaptive immunity. In: Immunologic Research. 2007 ; Vol. 37, No. 1. pp. 17-31.
@article{2a8b0691eb16439081426cd0915522c9,
title = "LIGHT-related molecular network in the regulation of innate and adaptive immunity",
abstract = "The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.",
keywords = "BTLA, HVEM, LIGHT, LTβR, T cell activation, T cell-mediated diseases",
author = "Yanhui Xu and Koji Tamada and Lieping Chen",
year = "2007",
month = "1",
doi = "10.1007/BF02686093",
language = "English (US)",
volume = "37",
pages = "17--31",
journal = "Immunologic Research",
issn = "0257-277X",
publisher = "Humana Press",
number = "1",

}

TY - JOUR

T1 - LIGHT-related molecular network in the regulation of innate and adaptive immunity

AU - Xu, Yanhui

AU - Tamada, Koji

AU - Chen, Lieping

PY - 2007/1

Y1 - 2007/1

N2 - The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.

AB - The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.

KW - BTLA

KW - HVEM

KW - LIGHT

KW - LTβR

KW - T cell activation

KW - T cell-mediated diseases

UR - http://www.scopus.com/inward/record.url?scp=34248362715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248362715&partnerID=8YFLogxK

U2 - 10.1007/BF02686093

DO - 10.1007/BF02686093

M3 - Article

C2 - 17496344

AN - SCOPUS:34248362715

VL - 37

SP - 17

EP - 31

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 1

ER -