Light-induced changes in pineal hydroxyindole-O-methyltransferase: Abolition by lateral hypothalamic lesions

Julius Axelrod, Solomon H. Snyder, Alfred Heller, Robert Y. Moore

Research output: Contribution to journalArticle


The activity of hydroxyindole-O-methyltransferase, the melatonin-forming enzyme in the pineal gland, is several times greater in rats kept in continuous darkness than in those kept in continuous light. Lesions transecting the medial forebrain bundle in the lateral hypothalamus suppress these differences in enzyme activity and abolish light-induced changes in pineal weight. These findings indicate that the medial forebrain bundle may participate in the control of this enzymatic response to environmental lighting.

Original languageEnglish (US)
Pages (from-to)898-899
Number of pages2
Issue number3751
StatePublished - Jan 1 1966


ASJC Scopus subject areas

  • General

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