Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro

Rui Duan, Ling Zhu, Timon Cheng Yi Liu, Yan Li, Jiang Liu, Jianling Jiao, Xiaoyang Xu, Libo Yao, Songhao Liu

Research output: Contribution to journalArticle

Abstract

Background and Objectives: Whether light emitting diode (LED) irradiation has effects on "β-amyloid (Aβ) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not? Study Design/Materials and Methods: Monolayer cell cultures of PC12 were subjected to Aβ or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay. Results: Treatment of the cells with LED irradiation significantly diminished Aβ induced apoptosis within 24 hours. Conclusions: The LED irradiation, when utilized at power of 0.9 W/m2 and 60 minutes has significantly diminished Aβ induced apoptosis of PC12 cells.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalLasers in Surgery and Medicine
Volume33
Issue number3
DOIs
Publication statusPublished - 2003
Externally publishedYes

    Fingerprint

Keywords

  • Alzheimer's disease
  • Apoptosis
  • Light emitting diode
  • PC12 cells

ASJC Scopus subject areas

  • Surgery

Cite this