Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro

Rui Duan; Ling Zhu; Timon Cheng Yi Liu; Yan Li; Jiang Liu; Jianling Jiao; Xiaoyang Xu; Libo Yao; Songhao Liu

doi:10.1002/lsm.10216

Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro

Rui Duan, Ling Zhu, Timon Cheng Yi Liu, Yan Li, Jiang Liu, Jianling Jiao, Xiaoyang Xu, Libo Yao, Songhao Liu

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Background and Objectives: Whether light emitting diode (LED) irradiation has effects on "β-amyloid (Aβ) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not? Study Design/Materials and Methods: Monolayer cell cultures of PC12 were subjected to Aβ or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay. Results: Treatment of the cells with LED irradiation significantly diminished Aβ induced apoptosis within 24 hours. Conclusions: The LED irradiation, when utilized at power of 0.9 W/m² and 60 minutes has significantly diminished Aβ induced apoptosis of PC12 cells.

Original language	English (US)
Pages (from-to)	199-203
Number of pages	5
Journal	Lasers in Surgery and Medicine
Volume	33
Issue number	3
DOIs	https://doi.org/10.1002/lsm.10216
State	Published - 2003
Externally published	Yes

Keywords

Alzheimer's disease
Apoptosis
Light emitting diode
PC12 cells

ASJC Scopus subject areas

Surgery
Dermatology

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10.1002/lsm.10216

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title = "Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro",

abstract = "Background and Objectives: Whether light emitting diode (LED) irradiation has effects on {"}β-amyloid (Aβ) induced apoptosis,{"} a leading hypothesis of the cause of Alzheimer's disease (AD), or not? Study Design/Materials and Methods: Monolayer cell cultures of PC12 were subjected to Aβ or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay. Results: Treatment of the cells with LED irradiation significantly diminished Aβ induced apoptosis within 24 hours. Conclusions: The LED irradiation, when utilized at power of 0.9 W/m2 and 60 minutes has significantly diminished Aβ induced apoptosis of PC12 cells.",

keywords = "Alzheimer's disease, Apoptosis, Light emitting diode, PC12 cells",

author = "Rui Duan and Ling Zhu and Liu, {Timon Cheng Yi} and Yan Li and Jiang Liu and Jianling Jiao and Xiaoyang Xu and Libo Yao and Songhao Liu",

year = "2003",

doi = "10.1002/lsm.10216",

language = "English (US)",

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pages = "199--203",

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TY - JOUR

T1 - Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro

AU - Duan, Rui

AU - Zhu, Ling

AU - Liu, Timon Cheng Yi

AU - Li, Yan

AU - Liu, Jiang

AU - Jiao, Jianling

AU - Xu, Xiaoyang

AU - Yao, Libo

AU - Liu, Songhao

PY - 2003

Y1 - 2003

N2 - Background and Objectives: Whether light emitting diode (LED) irradiation has effects on "β-amyloid (Aβ) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not? Study Design/Materials and Methods: Monolayer cell cultures of PC12 were subjected to Aβ or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay. Results: Treatment of the cells with LED irradiation significantly diminished Aβ induced apoptosis within 24 hours. Conclusions: The LED irradiation, when utilized at power of 0.9 W/m2 and 60 minutes has significantly diminished Aβ induced apoptosis of PC12 cells.

AB - Background and Objectives: Whether light emitting diode (LED) irradiation has effects on "β-amyloid (Aβ) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not? Study Design/Materials and Methods: Monolayer cell cultures of PC12 were subjected to Aβ or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay. Results: Treatment of the cells with LED irradiation significantly diminished Aβ induced apoptosis within 24 hours. Conclusions: The LED irradiation, when utilized at power of 0.9 W/m2 and 60 minutes has significantly diminished Aβ induced apoptosis of PC12 cells.

KW - Alzheimer's disease

KW - Apoptosis

KW - Light emitting diode

KW - PC12 cells

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Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro

Abstract

Keywords

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