LIGHT elevation enhances immune eradication of colon cancer metastases

Guilin Qiao, Jianzhong Qin, Nicholas Kunda, Jed F. Calata, Dolores L. Mahmud, Peter Gann, Yang Xin Fu, Steven A. Rosenberg, Bellur S. Prabhakar, Ajay V. Maker

Research output: Contribution to journalArticle

Abstract

The majority of patients with colon cancer will develop advanced disease, with the liver being the most common site of metastatic disease. Patients with increased numbers of tumorinfiltrating lymphocytes in primary colon tumors and liver metastases have improved outcomes. However, the molecular factors that could empower antitumor immune responses in this setting remain to be elucidated. We reported that the immunostimulatory cytokine LIGHT (TNFSF14) in the microenvironment of colon cancer metastases associates with improved patient survival, and here we demonstrate in an immunocompetent murine model that colon tumors expressing LIGHT stimulate lymphocyte proliferation and tumor cell-specific antitumor immune responses. In this model, increasing LIGHT expression in the microenvironment of either primary tumors or liver metastases triggered regression of established tumors and slowed the growth of liver metastases, driven by cytotoxic T-lymphocyte-mediated antitumor immunity. These responses corresponded with significant increases in tumor-infiltrating lymphocytes and increased expression of lymphocyte-homing signals in the metastatic tumors. Furthermore, we demonstrated evidence of durable tumor-specific antitumor immunity. In conclusion, increasing LIGHT expression increased T-cell proliferation, activation, and infiltration, resulting in enhanced tumorspecific immune-mediated tumor regressions in primary tumors and colorectal liver metastases. Mechanisms to increase LIGHT in the colon cancer microenvironment warrant further investigation and hold promise as an immunotherapeutic strategy.

Original languageEnglish (US)
Pages (from-to)1880-1891
Number of pages12
JournalCancer Research
Volume77
Issue number8
DOIs
StatePublished - Apr 15 2017
Externally publishedYes

Fingerprint

Colonic Neoplasms
Neoplasm Metastasis
Light
Neoplasms
Liver
Immunity
Colon
Cell Proliferation
Lymphocytes
Tumor-Infiltrating Lymphocytes
Tumor Microenvironment
Lymphocyte Count
Cytotoxic T-Lymphocytes
Liver Diseases
Colorectal Neoplasms
Cytokines
T-Lymphocytes
Survival
Growth

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Qiao, G., Qin, J., Kunda, N., Calata, J. F., Mahmud, D. L., Gann, P., ... Maker, A. V. (2017). LIGHT elevation enhances immune eradication of colon cancer metastases. Cancer Research, 77(8), 1880-1891. https://doi.org/10.1158/0008-5472.CAN-16-1655

LIGHT elevation enhances immune eradication of colon cancer metastases. / Qiao, Guilin; Qin, Jianzhong; Kunda, Nicholas; Calata, Jed F.; Mahmud, Dolores L.; Gann, Peter; Fu, Yang Xin; Rosenberg, Steven A.; Prabhakar, Bellur S.; Maker, Ajay V.

In: Cancer Research, Vol. 77, No. 8, 15.04.2017, p. 1880-1891.

Research output: Contribution to journalArticle

Qiao, G, Qin, J, Kunda, N, Calata, JF, Mahmud, DL, Gann, P, Fu, YX, Rosenberg, SA, Prabhakar, BS & Maker, AV 2017, 'LIGHT elevation enhances immune eradication of colon cancer metastases', Cancer Research, vol. 77, no. 8, pp. 1880-1891. https://doi.org/10.1158/0008-5472.CAN-16-1655
Qiao G, Qin J, Kunda N, Calata JF, Mahmud DL, Gann P et al. LIGHT elevation enhances immune eradication of colon cancer metastases. Cancer Research. 2017 Apr 15;77(8):1880-1891. https://doi.org/10.1158/0008-5472.CAN-16-1655
Qiao, Guilin ; Qin, Jianzhong ; Kunda, Nicholas ; Calata, Jed F. ; Mahmud, Dolores L. ; Gann, Peter ; Fu, Yang Xin ; Rosenberg, Steven A. ; Prabhakar, Bellur S. ; Maker, Ajay V. / LIGHT elevation enhances immune eradication of colon cancer metastases. In: Cancer Research. 2017 ; Vol. 77, No. 8. pp. 1880-1891.
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