TY - JOUR
T1 - Light Affects Mood and Learning through Distinct Retina-Brain Pathways
AU - Fernandez, Diego Carlos
AU - Fogerson, P. Michelle
AU - Lazzerini Ospri, Lorenzo
AU - Thomsen, Michael B.
AU - Layne, Robert M.
AU - Severin, Daniel
AU - Zhan, Jesse
AU - Singer, Joshua H.
AU - Kirkwood, Alfredo
AU - Zhao, Haiqing
AU - Berson, David M.
AU - Hattar, Samer
N1 - Funding Information:
We would like to thank the Johns Hopkins Biology Mouse Tri-Lab—especially Dr. Rejji Kuruvilla—for support and discussion; the Department of Biology at the University of Maryland and Dianne and Kimberly Boghossian for assistance maintaining and genotyping mice; Dr. Antonello Bonci, Dr. Yeka Aponte, and their lab members for help addressing reviewers’ concerns; and Elaine Nguyen for help with tracer injections. We would like to thank Mio Akasako for her key assistance with the retrolabeling experiments. This work was supported by the NIH (GM076430, EY027202, EY012793, and EY017137), the generous contributions of the Alcon Research Institute (to D.M.B.), PEW Charitable Trusts (to D.C.F.), the NSF (I2011104359 to P.M.F.), and the intramural research at the National Institute of Mental Health.
Funding Information:
We would like to thank the Johns Hopkins Biology Mouse Tri-Lab—especially Dr. Rejji Kuruvilla—for support and discussion; the Department of Biology at the University of Maryland and Dianne and Kimberly Boghossian for assistance maintaining and genotyping mice; Dr. Antonello Bonci, Dr. Yeka Aponte, and their lab members for help addressing reviewers’ concerns; and Elaine Nguyen for help with tracer injections. We would like to thank Mio Akasako for her key assistance with the retrolabeling experiments. This work was supported by the NIH ( GM076430 , EY027202 , EY012793 , and EY017137 ), the generous contributions of the Alcon Research Institute (to D.M.B.), PEW Charitable Trusts (to D.C.F.), the NSF ( I2011104359 to P.M.F.), and the intramural research at the National Institute of Mental Health .
Publisher Copyright:
© 2018
PY - 2018/9/20
Y1 - 2018/9/20
N2 - Light exerts a range of powerful biological effects beyond image vision, including mood and learning regulation. While the source of photic information affecting mood and cognitive functions is well established, viz. intrinsically photosensitive retinal ganglion cells (ipRGCs), the central mediators are unknown. Here, we reveal that the direct effects of light on learning and mood utilize distinct ipRGC output streams. ipRGCs that project to the suprachiasmatic nucleus (SCN) mediate the effects of light on learning, independently of the SCN's pacemaker function. Mood regulation by light, on the other hand, requires an SCN-independent pathway linking ipRGCs to a previously unrecognized thalamic region, termed perihabenular nucleus (PHb). The PHb is integrated in a distinctive circuitry with mood-regulating centers and is both necessary and sufficient for driving the effects of light on affective behavior. Together, these results provide new insights into the neural basis required for light to influence mood and learning. The effects of light on learning and mood via intrinsically photosensitive retinal ganglion cells involve a pacemaker-independent role for the suprachiasmatic nucleus as well as distinct circuitry in a region of the thalamus called the perihabenular nucleus.
AB - Light exerts a range of powerful biological effects beyond image vision, including mood and learning regulation. While the source of photic information affecting mood and cognitive functions is well established, viz. intrinsically photosensitive retinal ganglion cells (ipRGCs), the central mediators are unknown. Here, we reveal that the direct effects of light on learning and mood utilize distinct ipRGC output streams. ipRGCs that project to the suprachiasmatic nucleus (SCN) mediate the effects of light on learning, independently of the SCN's pacemaker function. Mood regulation by light, on the other hand, requires an SCN-independent pathway linking ipRGCs to a previously unrecognized thalamic region, termed perihabenular nucleus (PHb). The PHb is integrated in a distinctive circuitry with mood-regulating centers and is both necessary and sufficient for driving the effects of light on affective behavior. Together, these results provide new insights into the neural basis required for light to influence mood and learning. The effects of light on learning and mood via intrinsically photosensitive retinal ganglion cells involve a pacemaker-independent role for the suprachiasmatic nucleus as well as distinct circuitry in a region of the thalamus called the perihabenular nucleus.
KW - aberrant light cycle
KW - circadian rhythms
KW - ipRGCs
KW - learning
KW - mood
KW - perihabenular nucleus
KW - suprachiasmatic nucleus
KW - ventromedial prefrontal cortex
UR - http://www.scopus.com/inward/record.url?scp=85053695958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053695958&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2018.08.004
DO - 10.1016/j.cell.2018.08.004
M3 - Article
C2 - 30173913
AN - SCOPUS:85053695958
SN - 0092-8674
VL - 175
SP - 71-84.e18
JO - Cell
JF - Cell
IS - 1
ER -