Lifetime growth hormone (GH) deficiency: Impact on growth, metabolism, body composition, and survival capacity

Manuel Herminio Aguiar-Oliveira, Roberto Salvatori

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A model of growth hormone (GH) deficiency (GHD) due to GH-releasing hormone (GHRH) resistance caused by a homozygous-inactivating mutation in the GHRH receptor gene was used to assess the impacts of lifetime GH deficiency on growth, metabolism, body composition, and survival capacity. Affected individuals go through life with very low activity of the GH-insulin-like growth factor-I (IGF-I) axis. As a result, they present severe short stature with adult height standard deviation score from - 9.6 to -5.1 and proportionate reduction of bone dimensions. The reduction of the cephalic perimeter is less accentuated than the reduction on the facial height, causing a disproportion between the calvarium and the face, resulting in a "doll" or cherubim angel facies, which together with the underdevelopment of larynx leads to high pitch voice. Even when corrected by body surface, they have reduced size of the pituitary, thyroid, heart, uterus, and spleen. They also exhibit an increase in total and LDL cholesterol that persists throughout adulthood together with high levels of C-reactive protein and higher blood pressure. Body composition is markedly changed since childhood with reduction in fat-free mass with a mirror increase in percent fat mass. Despite this, they have an increase in insulin sensitivity. Bone strength is somewhat reduced without apparent increase in fractures. Puberty is delayed, but reproductive life and quality of life are normal. Despite unfavorable metabolic, inflammatory, blood pressure, and body composition profile, they did not exhibit premature atherosclerosis, with longevity similar to their normal-stature relatives.

Original languageEnglish (US)
Title of host publicationHandbook of Growth and Growth Monitoring in Health and Disease
PublisherSpringer New York
Pages2699-2710
Number of pages12
ISBN (Electronic)9781441917959
ISBN (Print)9781441917942
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Nursing(all)

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