Lifetime comorbidity of panic attacks and major depression in a population-based study. Symptom profiles

L. Andrade, William W Eaton, H. Chilcoat

Research output: Contribution to journalArticle

Abstract

Background. The co-occurrence of panic disorder and major depression in the same individual is common. A question to be answered is whether the comorbid disorder is a distinct one or may resemble one or other disorder. In this paper we examine whether the comorbid disorder is a distinct condition. Method. We examined the symptom profiles and rates of comorbidity of panic attacks and DIS/DSM-III major depressive disorder in a population-based sample from four sites of the National Institute of Mental Health (NIMH) Epidemiologic Catchment Area Program (n = 12 668). Results. The co-occurrence of panic attacks and major depression over the lifetime was 11 times higher than expected by chance (OR = 11.4, 95% CI 9.5 to 13.6). Subjects with both panic and depression had worse symptoms than those who had only one disorder. However, the pattern of symptoms was remarkably similar, after overall severity was taken into account. Depressive symptoms associated with more severe forms of depression (e.g. guilt, suicidal thoughts or attempts, and motor disturbance) were more frequent in the comorbid group. Conclusions. These findings may indicate a worse severity when the two disorders occur in the same individual.

Original languageEnglish (US)
Pages (from-to)363-369
Number of pages7
JournalBritish Journal of Psychiatry
Volume165
Issue numberSEP.
StatePublished - 1994
Externally publishedYes

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Panic Disorder
Comorbidity
Depression
Population
National Institute of Mental Health (U.S.)
Panic
Guilt
Major Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Lifetime comorbidity of panic attacks and major depression in a population-based study. Symptom profiles. / Andrade, L.; Eaton, William W; Chilcoat, H.

In: British Journal of Psychiatry, Vol. 165, No. SEP., 1994, p. 363-369.

Research output: Contribution to journalArticle

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