TY - JOUR
T1 - Lifestyle behavior pattern is associated with different levels of risk for incident dementia and Alzheimer's disease
T2 - The Cache County study
AU - Norton, Maria C.
AU - Dew, Jeffrey
AU - Smith, Heeyoung
AU - Fauth, Elizabeth
AU - Piercy, Kathleen W.
AU - Breitner, John C.S.
AU - Tschanz, Joann
AU - Wengreen, Heidi
AU - Welsh-Bohmer, Kathleen
PY - 2012/3
Y1 - 2012/3
N2 - Objectives To identify distinct behavioral patterns of diet, exercise, social interaction, church attendance, alcohol consumption, and smoking and to examine their association with subsequent dementia risk. Design Longitudinal, population-based dementia study. Setting Rural county in northern Utah, at-home evaluations. Participants Two thousand four hundred ninety-one participants without dementia (51% male, average age 73.0 ± 5,7; average education 13.7 ± 4.1 years) initially reported no problems in activities of daily living and no stroke or head injury within the past 5 years. Measurements Six dichotomized lifestyle behaviors were examined (diet: high ≥ median on the Dietary Approaches to Stop Hypertension scale; exercise: ≥5 h/wk of light activity and at least occasional moderate to vigorous activity; church attendance: attending church services at least weekly; social Interaction: spending time with family and friends at least twice weekly; alcohol: currently drinking alcoholic beverages ≥ 2 times/wk; nonsmoker: no current use or fewer than 100 cigarettes ever). Latent class analysis (LCA) was used to identify patterns among these behaviors. Proportional hazards regression modeled time to dementia onset as a function of behavioral class, age, sex, education, and apolipoprotein E status. Follow-up averaged 6.3 ± 5.3 years, during which 278 cases of incident dementia (200 Alzheimer's disease (AD)) were diagnosed. Results LCA identified four distinct lifestyle classes. Unhealthy-religious (UH-R; 11.5%), unhealthy-nonreligious (UH-NR; 10.5%), healthy-moderately religious (H-MR; 38.5%), and healthy-very religious (H-VR; 39.5%). UH-NR (hazard ratio (HR) = 0.54, P =.028), H-MR (HR = 0.56, P =.003), and H-VR (HR = 0.58, P =.005) had significantly lower dementia risk than UH-R. Results were comparable for AD, except that UH-NR was less definitive. Conclusion Functionally independent older adults appear to cluster into subpopulations with distinct patterns of lifestyle behaviors with different levels of risk for subsequent dementia and AD.
AB - Objectives To identify distinct behavioral patterns of diet, exercise, social interaction, church attendance, alcohol consumption, and smoking and to examine their association with subsequent dementia risk. Design Longitudinal, population-based dementia study. Setting Rural county in northern Utah, at-home evaluations. Participants Two thousand four hundred ninety-one participants without dementia (51% male, average age 73.0 ± 5,7; average education 13.7 ± 4.1 years) initially reported no problems in activities of daily living and no stroke or head injury within the past 5 years. Measurements Six dichotomized lifestyle behaviors were examined (diet: high ≥ median on the Dietary Approaches to Stop Hypertension scale; exercise: ≥5 h/wk of light activity and at least occasional moderate to vigorous activity; church attendance: attending church services at least weekly; social Interaction: spending time with family and friends at least twice weekly; alcohol: currently drinking alcoholic beverages ≥ 2 times/wk; nonsmoker: no current use or fewer than 100 cigarettes ever). Latent class analysis (LCA) was used to identify patterns among these behaviors. Proportional hazards regression modeled time to dementia onset as a function of behavioral class, age, sex, education, and apolipoprotein E status. Follow-up averaged 6.3 ± 5.3 years, during which 278 cases of incident dementia (200 Alzheimer's disease (AD)) were diagnosed. Results LCA identified four distinct lifestyle classes. Unhealthy-religious (UH-R; 11.5%), unhealthy-nonreligious (UH-NR; 10.5%), healthy-moderately religious (H-MR; 38.5%), and healthy-very religious (H-VR; 39.5%). UH-NR (hazard ratio (HR) = 0.54, P =.028), H-MR (HR = 0.56, P =.003), and H-VR (HR = 0.58, P =.005) had significantly lower dementia risk than UH-R. Results were comparable for AD, except that UH-NR was less definitive. Conclusion Functionally independent older adults appear to cluster into subpopulations with distinct patterns of lifestyle behaviors with different levels of risk for subsequent dementia and AD.
KW - dementia
KW - health-related behaviors
KW - lifestyle
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U2 - 10.1111/j.1532-5415.2011.03860.x
DO - 10.1111/j.1532-5415.2011.03860.x
M3 - Article
C2 - 22316091
AN - SCOPUS:84858332475
SN - 0002-8614
VL - 60
SP - 405
EP - 412
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 3
ER -