TY - JOUR
T1 - Lichenoid Chronic Graft-vs-Host Disease Occurring in a Dermatomal Distribution
AU - Freemer, Christine S.
AU - Farmer, Evan R.
AU - Corio, Russell L.
AU - Altomonte, Viki L.
AU - Wagner, John E.
AU - Vogelsang, Georgia B.
AU - Santos, George W.
PY - 1994/1
Y1 - 1994/1
N2 - Background: Chronic graft-vs-host disease (GVHD) is a late complication of allogeneic bone marrow transplantation and is associated with high morbidity and mortality. While the pathogenesis of chronic GVHD is not fully understood, several observations and studies suggest that viral infections may play a role. We describe two patients who developed linear lichenoid chronic GVHD. The dermatomal distribution of their lesions suggests an association with herpes zoster virus infection. Results: Two allogeneic bone marrow transplantation patients developed violaceous papules in a dermatomal distribution. Histologic examination of these lesions revealed dyskeratosis, vacuolar changes in the basal layer, and a mild perivascular and interstitial infiltrate, diagnostic of lichenoid chronic GVHD. Conclusions: The linear distribution of our ' lichenoid chronic GVHD is unique and may represent an association with herpes zoster virus infection, providing further support for a role for viral infections in the pathogenesis of chronic GVHD.
AB - Background: Chronic graft-vs-host disease (GVHD) is a late complication of allogeneic bone marrow transplantation and is associated with high morbidity and mortality. While the pathogenesis of chronic GVHD is not fully understood, several observations and studies suggest that viral infections may play a role. We describe two patients who developed linear lichenoid chronic GVHD. The dermatomal distribution of their lesions suggests an association with herpes zoster virus infection. Results: Two allogeneic bone marrow transplantation patients developed violaceous papules in a dermatomal distribution. Histologic examination of these lesions revealed dyskeratosis, vacuolar changes in the basal layer, and a mild perivascular and interstitial infiltrate, diagnostic of lichenoid chronic GVHD. Conclusions: The linear distribution of our ' lichenoid chronic GVHD is unique and may represent an association with herpes zoster virus infection, providing further support for a role for viral infections in the pathogenesis of chronic GVHD.
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U2 - 10.1001/archderm.1994.01690010074010
DO - 10.1001/archderm.1994.01690010074010
M3 - Article
C2 - 8285743
AN - SCOPUS:0028044766
SN - 0003-987X
VL - 130
SP - 70
EP - 72
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 1
ER -