Lewy body disease: Can we diagnose it?

Michelle Papka, Ana Rubio, Randolph B. Schiffer, Christopher Cox

Research output: Contribution to journalArticlepeer-review


The authors assessed the accuracy of published clinical criteria and their own modifications of those criteria in diagnosing Lewy body disease (LBD). Clinical diagnoses were made by two clinicians, blinded to neuropathologic diagnoses, using the Rochester Alzheimer's Disease Center database and traditional medical records. Neuropathologic diagnoses were made according to published guidelines. Results from 21 Alzheimer's disease and 18 LBD patients indicated that no set of clinical criteria was accurate in diagnosing LBD. The only significant predictor of LBD in this population was depression, which was more common in LBD than in Alzheimer's disease. The authors conclude that clinical identification of LBD is an important but unresolved neurological problem.

Original languageEnglish (US)
Pages (from-to)405-412
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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