Our previous studies have shown specific IgE response directed to HIV. The present study evaluated total IgE levels in relationship to other viral infections in a population living in San Andres Island. Total IgE levels, Hepatitis B and C, HIV and dengue infections were determined in a cross-sectional study of randomly chosen group of individuals, (n=169) representing the general population of San Andres Island. The participants (90 women and 79 men) ranged in age from 13 to 76 years. IgE logarithmic transformation was used for the analysis. Eighty nine percent of the island population exhibited abnormally high levels of total IgE (≥ 100 IU). The mean and standard error measurements of the IgE in our population was 279.3 ± 12.8 IU/ml. A total of 148 individuals were seropositive for at least one viral infection versus 21 subjects who were seronegatives. Univariate Analysis revealed that those seropositive subjects were 3 times more like to have abnormal IgE levels that those who were seronegatives (OR=3.3, CI 95%: 1.17 9.31, p=0.02). This study demonstrates markedly high IgE levels in the majority of San Andres Island individuals and extends earlier findings to indicate that viral infections may be an important factor in the IgE elevation observed in the Island.
|Original language||English (US)|
|State||Published - Mar 20 1998|
ASJC Scopus subject areas
- Molecular Biology