Levels of neurotransmitter and cytoskeletal protein mRNAs during nerve regeneration in sympathetic ganglia

Edward H. Koo, P. N. Hoffman, D. L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

The present study examines levels of neurotransmitter messenger RNA (mRNA) at various stages after crush of postganglionic nerves in the superior cervical ganglia. Using complementary DNA (cDNA) probes, we demonstrated a reduction in ganglionic mRNA levels for tyrosine hydroxylase (TH) after axotomy. Concomitantly, actin and tubulin mRNA levels in ganglia were increased. Thus, in neurons of sympathetic ganglia, axotomy appears to be associated with a selective reduction in levels of TH mRNA, and, in turn, alters levels of protein and enzyme activities.

Original languageEnglish (US)
Pages (from-to)361-363
Number of pages3
JournalBrain research
Volume449
Issue number1-2
DOIs
StatePublished - May 24 1988

Keywords

  • Axotomy
  • Gene expression
  • Neuronal gene
  • Nucleic acid hybridization
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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