@article{d6e40cda585446a2bb16087deda1f183,
title = "Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation",
abstract = "Scratching triggers skin flares in atopic dermatitis. We demonstrate that scratching of human skin and tape stripping of mouse skin cause neutrophil influx. In mice, this influx was largely dependent on the generation of leukotriene B4 (LTB4) by neutrophils and their expression of the LTB4 receptor BLT1. Allergic skin inflammation in response to epicutaneous (EC) application of ovalbumin to tape-stripped skin was severely impaired in Ltb4r1-/- mice and required expression of BLT1 on both T cells and non-T cells. Cotransfer of wild-type (WT) neutrophils, but not neutrophils deficient in BLT1 or the LTB4-synthesizing enzyme LTA4H, restored the ability of WT CD4+ effector T cells to transfer allergic skin inflammation to Ltb4r1-/- recipients. Pharmacologic blockade of LTB4 synthesis inhibited allergic skin inflammation elicited by cutaneous antigen challenge in previously EC-sensitized mice. Our results demonstrate that a neutrophil-T cell axis reliant on LTB4-BLT1 interaction is required for allergic skin inflammation.",
author = "Oyoshi, {Michiko K.} and Rui He and Yitang Li and Subhanjan Mondal and Juhan Yoon and Roshi Afshar and Mei Chen and Lee, {David M.} and Luo, {Hongbo R.} and Luster, {Andrew D.} and Cho, {John S.} and Miller, {Lloyd S.} and Allison Larson and Murphy, {George F.} and Geha, {Raif S.}",
note = "Funding Information: This work was supported by the Atopic Dermatitis Research Network National Institutes of Health/National Institute of Allergy and Infectious Diseases contract HHSN272201000020C (R.S.G.); U.S. Public Health Service grants AR-047417 (R.S.G.), AI 065858-03 (D.M.L.) HL-085100, AI-076471, and HL-092020, GM-076084; a Research Scholar Grant from the American Cancer Society (H.R.L.); and AI-050892 and AI-040618 (A.D.L.), R01 AI078910 (L.S.M.), T32 AR058921 (J.S.C.), R24 CA92865 (UCLA Small Animal Imaging Resource Program); and the Boston Children{\textquoteright}s Hospital Faculty Career Development Fellowship (M.K.O.). D.M.L. is currently an employee of Novartis Pharma AG and owns stock and/or options >$10,000 and has ownership and consulting income >$10,000 from Synovex. M.C. is currently an employee of Pfizer. We thank M.J. Massaad and H.C. Oettgen for reading the manuscript. We also thank J. Beaupre for her technical assistance. ",
year = "2012",
month = oct,
day = "19",
doi = "10.1016/j.immuni.2012.06.018",
language = "English (US)",
volume = "37",
pages = "747--758",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",
}