Leukoencephalopathy with vanishing white matter: Serial MRI of the brain and spinal cord including diffusion tensor imaging

A. Meoded, A. Poretti, S. Yoshida, T. A.G.M. Huisman

Research output: Contribution to journalArticlepeer-review

Abstract

Vanishing white matter disease (VWM) is one of the most frequent inherited childhood white matter disorders. We present the brain and spinal cord disease progression on serial conventional magnetic resonance imaging (MRI) and diff usion tensor imaging (DTI) in a 4-year-old boy. Consecutive MRI examinations demonstrated a progression of the signal abnormalities in the cerebral white matter. Globally, apparent diff usion coeffi cient (ADC) values as well as axial and radial diff usivity increased over time, while fractional anisotropy (FA) values decreased. Involvement of the cervical posterior spinal tracts and mild global spinal cord atrophy was found. In conclusion, serial MRI and DTI studies may help to better understand the selective injury of the myelin and axons in VWM disease. These data may help in monitoring disease progression. Our data also show that complete neuroimaging work-up in VWM should also include the spinal cord.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalNeuropediatrics
Volume42
Issue number2
DOIs
StatePublished - Jul 6 2011

Keywords

  • MR spectroscopy
  • diff usion tensor imaging
  • neuroimaging
  • spinal cord
  • vanishing white matter disease
  • white matter disorders

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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