Leukodystrophy: Basic and clinical

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Leukodystrophies are serious, progressive, genetic disorders of CNS myelin. They may result from abnormalities of the oligodendrocyte or any of the other of myriad of supporting cells or tissues. With recent developments in neuroimaging, their presence is becoming increasingly noted even in situations where they were not suspected. More importantly, new genetic tools have improved our ability to diagnose. An understanding of pathogenesis is still evolving, but it is expected that this will assist in developing targeted therapies for these devastating disorders.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer New York LLC
Pages365-382
Number of pages18
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Publication series

NameAdvances in Neurobiology
Volume15
ISSN (Print)2190-5215

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Keywords

  • Adrenoleukodystrophy
  • Alexander disease
  • Globoid cell leukodystrophy
  • Leukodystrophy
  • Myelin

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Raymond, G. V. (2017). Leukodystrophy: Basic and clinical. In Advances in Neurobiology (pp. 365-382). (Advances in Neurobiology; Vol. 15). Springer New York LLC. https://doi.org/10.1007/978-3-319-57193-5_14